Effect of weight reduction resulting from life style modification or bariatric surgery on pancreas fat accumulation and beta cell function in Japanse type 2 diabetes.

Not Applicable

• Conditions: type 2 diabetes, obesity

• Registration Number: JPRN-UMIN000013396
• Lead Sponsor: The University of Tokushima

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-04-01
• Study Completion: 2015-12-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

1. Diabetes other than type 2 diabetes. 2. Patients who have a disease other than obesity related disease. 3. Patients who have a disease which is associated with the risk of surgery. 4. Patients who have mental disorder. 5. Excessive alcohol drinker. 6. Female patients who are willing to be pregnant and give a birth. 7. Patients who are not willing to lose weight. 8. Patients who are decided to be inadequete for participating this study by physitian in charge. 9. Patients who are decided to have a risk for baritric surgery by physitian in charge.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Insulin secretion before and after intervention. a. OGTT. b. Disposition Index (dual glucose clamp method). 2. Glucagon load test before and after intervention. 3. Pancreas fat before and after intervention. 4. Insulin secretion between two groups. a. OGTT. b. Disposition Index (dual glucose clamp method). 5. Glucagon load test between two groups. 6. Pancreas fat content between two groups. 7. Correlation between fat content and disposition index.

Secondary Outcome Measures

Name	Time	Method
1. Change of HbA1c levels before and after intervention. 2. Change of fasting glucagon levels before and after intervention. 3. Change of gastrointestinal hormones before and after intervention. 4. Comparison of HbA1c levels between two groups. 5. Comparison of fasting glucagon levels between two groups. 6. Comparison of gastrointestinal hormones between two groups.