ong-Term Effect of Goal directed weight management on Atrial Fibrillation Cohort: A 5 Year follow-up study

Not Applicable

Completed

• Conditions: Atrial Fibrillation burden; obesity; Cardiovascular - Other cardiovascular diseases; Diet and Nutrition - Obesity

• Registration Number: ACTRN12614001123639
• Lead Sponsor: Adelaide University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-10-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 356

Inclusion Criteria

Age: 18 – 85 years
paroxysmal or persistent AF
Paroxysmal AF defined as recurrent episodes that self-terminate within 7 days or persistent AF as recurrent episodes that last more than 7 days and may be terminated with cardioversion.
Stable or no coronary artery disease.
Risk Factors identified at initial assessment including obesity (BMI>27), hypertension, diabetes, smoking and ETOH abuse.

Exclusion Criteria

Significant cardiac valvulopathy
Significant left ventricular systolic dysfunction (EF less than or equal than 45% on Simpson biplane estimation or regional wall motion abnormalities), obvious LV regional wall motion abnormality, dilated LV
Myocardial infraction or cardiac surgery in the previous 12 months, and previous ablation for AF
Right ventricular dysfunction with or without pulmonary hypertension (resting PASP equal to 45mmHg) and/or at least moderate tricuspid regurgitation
Congenital heart disease
Severe coronary heart disease.
Uncontrolled endocrinopathy (adrenal, thyroid, etc.)
Severe medical condition such as malignancies, autoimmune or inflammatory diseases, renal failure, or hepatic failure

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in AF burden as assessed by 7 days Holter study and AF symptom severity score (AFSS)[Long term follow up with annual follow up until five years]