Diagnosing chronic cough with a capsaicin provocation test
Phase 2
Withdrawn
- Conditions
- Sensory hyperreactivity10006436
- Registration Number
- NL-OMON41167
- Lead Sponsor
- Orbis Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Mentally competent;
18 years and older;
Chronic cough;
Normal long function (FEV1, VC and ratio > 80% of predicted values);
Negative histamine provocation test (max fall FEV1 off 10%);
Non smokers;
No other pulmonary diseases.
Exclusion Criteria
Not mentally competent;
No cough;
Other pulmonary diseases;
Post nasal drip;
Gastro-oesofageal reflux;
Deviation on x-ray;
No normal values in long function;
Lung infection in the past eight weeks;
Use of ACE-inhibitor;
Excessive mucus production;
Pregnancy or pregnancy wish;
Breastfeeding.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>All data will be recorded in the pulmonary function laboratory of the Orbis<br /><br>Medical Center in Sittard.<br /><br><br /><br>The variables that are collected during this studyare divided in the dependent<br /><br>and independent variables. The dependent variables are the number of coughs en<br /><br>the deposit score for chest pain, haorseness, irritation of the throat, runny<br /><br>nose, mucus and irritation of the eyes. The independent variables are<br /><br>concentration inhaled capsaicin, gender and age.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Inapplicable</p><br>