Validation study of the Graded Prognostic Assessment Score (to predict survival) in brain metastases (disease which has spread to the brain) of patients with lung cancer
Not Applicable
- Conditions
- Health Condition 1: C793- Secondary malignant neoplasm of brain and cerebral meninges
- Registration Number
- CTRI/2023/03/050413
- Lead Sponsor
- Tata Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Age >= 18 years
2) Histopathological proven cases of lung cancer.
3) Radiologically confirmed brain metastasis
4) The patient planned for cranial radiotherapy (WBRT/Focal RT)
5) Patient willing to sign a written consent form.
Exclusion Criteria
1) Patients with prior history of radiation therapy for brain metastases (excluding prior Stereotactic Radiosurgery)
2) Patients who are not willing to come for follow up at Tata Memorial Hospital (TMH)/ Advanced Centre for Treatment, Research and Education in Cancer (ACTREC)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To validate the Lung Specific Graded Prognostic Assessment score in brain metastasesTimepoint: 6 month
- Secondary Outcome Measures
Name Time Method 1) To validate lung molecular GPA. <br/ ><br>2) To assess survival outcomes at 6, 12 and 24 months. <br/ ><br>3) To evaluate the 30-day mortality. <br/ ><br>4) To validate other prognostic indices such as RPA, SIRS, BSBM, SIPS and to see concordance between them. <br/ ><br>5) To assess the patient-reported outcomes in the prospective cohort.Timepoint: 1 month, 6 months, 12 months, 24 months