Effects of resistance training combined with increased dietary protein (red meat) on muscle and brain health, and cognitive function in community-dwelling older adults: The Seniors Thinking, Exercise and Protein Study (STEPS)

Not Applicable

Completed

• Conditions: Age-related loss of muscle size and function (sarcopenia); Age-related decline in cognitive function; Diet and Nutrition - Other diet and nutrition disorders; Musculoskeletal - Other muscular and skeletal disorders; Mental Health - Other mental health disorders

• Registration Number: ACTRN12613001153707
• Lead Sponsor: Deakin University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-10-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 152

Inclusion Criteria

Community-dwelling men and women aged 65 years and over. All participants enrolled in the study must also have received approval from their local physician to participate in the community-based intervention.

Exclusion Criteria

Participants will be excluded on the following criteria: 1) aged <65 years; 2) current or prior participation in resistance exercise (>1 week) and/or moderate-intensity physical activity greater than or equal to 150 minutes per week in the past 3 months; 3) acute or terminal illness, including current (treated or untreated) cancer or surgery/cessation of chemotherapy/radiotherapy less than 12-months ago; 4) history of a recent low trauma fracture with functional impairment that would limit participation in the exercise program; 5) body mass index (BMI) >40; 6) use of insulin to treat diabetes; 7) chronic liver disease, coeliac or inflammatory bowel disease, including ulcerative colitis or Crohn’s disease; 8) recent use of corticosteroids (past 6 months); or 9) inability to commit to the study and its requirements. Participants will not be excluded if they were currently taking vitamin D supplements, but will be asked to take the vitamin D that was provided as part of the study.

Eligible participants will then be screened using the Short Portable Mental Status Questionnaire (SPMSQ) and the Geriatric Depression Scale (GDS) to evaluate whether they are cognitively healthy and have no signs of depression. Those with a score of greater than two on the SPMSQ and/or a score of greater than six on the GDS will be excluded from the study. Participants that remained eligible will then be required to obtain approval from their local doctor to clear them of any contraindicated medical conditions to exercise, based upon American College of Sports Medicine (ACSM) guidelines, to participate in the program. Finally, participants will be asked to provide a fasted, morning blood sample to confirm that their estimated Glomerular Filtration Rate (eGFR) was >45 mL/min/1.73m2.

Study & Design

• Study Type: Interventional
• Study Design: Not specified