Correlation Between Exhaled Propofol Concentration With Plasma Concentration in Children
- Conditions
- Eye Diseases
- Interventions
- Device: Edmon
- Registration Number
- NCT04150432
- Lead Sponsor
- Oslo University Hospital
- Brief Summary
Children due for elective eye surgery in propofol based anesthesia will be kept at steady state propofol infusion for maintenance, ventilation via endotracheal tube. Exhaled propofol will be measured continously by Edmon (R) (BBraun) monitor and compared with arterial plasma samples of propofol, drawn 3-5 times during the procedure.
- Detailed Description
The primary objective of the study is to determine the correlation between simultaneous concentrations of propofol in plasma and expiratory air in children during general anesthesia.
Key secondary objectives include correlating plasma and exhaled measurements of propofol with electroencephalogram (BIS) values and computer estimated propofol concentrations in plasma and brain (TCI: target control infusion) Primary endpoint: Exhaled air and plasma concentration ratios of propofol during general anesthesia in children.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
- elective eye surgey
- known propofol hypersensitivity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description propofol Edmon propofol general anesthesia, exhaled measurement of propofol
- Primary Outcome Measures
Name Time Method Propofol plasma concentration versus simultaneous exhaled concentration 5 hours repeated blood samples of propofol concentration
- Secondary Outcome Measures
Name Time Method Propofol exhaled correlation versus Bispectral Index value (BIS) 5 hours repeated blood samples of propofol concentration
Trial Locations
- Locations (1)
Oslo University Hospital
🇳🇴Oslo, Norway