ISRCTN45773760已完成不适用
Do xanthine oxidase inhibitors reduce both left ventricular hypertrophy and endothelial dysfunction in cardiovascular patients with renal dysfunction?
niversity of Dundee (UK)0 个研究点目标入组 60 人开始时间: 2008年6月26日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Both males and females, age >18 years old and there is no upper age limit
- •2. Chronic kidney disease, Stage 3 (estimated glomerular filtration rate [GFR] 30-60 ml/min)
- •3. Echo left ventricular hypertrophy
排除标准
- •1. Known cardiac failure with left ventricular ejection fraction (LVEF) <45%
- •2. Patients already on allopurinol
- •3. Patients who have gout
- •4. Patients with severe hepatic disease
- •5. Usual contraindications to magnetic resonance imaging (MRI), including any metal implants in the body and severe claustrophobia
- •6. Current immunosuppressive therapy (e.g., azathioprine, ciclosporin or cyclophosphamide), chlorpropamide, theophylline or 6-mercaptopurine
- •7. Malignancy or other life threatening disease
- •8. Pregnancy and lactating women
- •9. Patients unable to provide informed consent (e.g., learning difficulties)
研究者
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