calculation of renal function by two different methods (renal scan method and bedside method) in sick children admitted to IC

Not Applicable

• Conditions: Health Condition 1: null- children aged (corrected age) 1 month to 12 years admitted in PICU, will be included in the study within 24 hours of admission to PICU with stable hemodynamic parameters

• Registration Number: CTRI/2017/10/010014
• Lead Sponsor: The Director

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

All children aged (corrected age) 1 month to 12 years admitted in PICU, will be included in the study within 24 hours of admission to PICU with stable hemodynamic parameters (i.e Achieved immediate resuscitation goals (as directed by the treating physician) including fluid resuscitation AND/OR vasoactive therapy to achieve capillary refill of <=2 secs, >5th percentile mean arterial blood pressure (MABP) for age, sex and length/height, normal pulses volume with no differential between peripheral and central pulses and urine output more than 1ml/kg/hour for at least 6 hours. Central venous pressure >=8 cmH2O (if measured), central venous oxygen saturation >=70% (if measured) AND/OR cardiac index between 3.3 and 6.0 L/min/m2 (if measured) and remain stable for 6-hours.

Exclusion Criteria

1. Patient with >= Stage 4 chronic kidney disease (defined by an estimated glomerular filtration rate <30 mL/min/ 1.73 m2), end-stage kidney disease on chronic dialysis, kidney transplantation or already received dialysis in PICU.

2. Patient requiring renal replacement therapy (RRT) at admission/prior to enrollment.

3. Patient with known or suspected obstructive etiology for AKI.

4. Patients with severe acute malnutrion as per World Health Organization (WHO) classification (presence of bipedal edema of nutritional origin, weight-for-height or weight-for-length: Z-score <â??3, presence of visible severe wasting), a mid-upper-arm-circumference <11.5cm (in children > 6months <60 months).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study the strength of agreement between the measured GFR by DTPA renal scan and estimated GFR by modified Schwartz formula in critically ill children at admission in PICU.Timepoint: Within 24 hours (during PICU stay).

Secondary Outcome Measures

Name	Time	Method
1. To study the incidence of AKI in critically ill children at admission and during the PICU stays using p-RIFLE criteria.Timepoint: At 28 days (PICU stay);2. To study the time taken to achieve the renal recovery in the patients having AKI.Timepoint: At 28 days (PICU stay);3. To study the 28-days mortality rates in the patients having AKI and no AKI.Timepoint: At 28 days (PICU stay);4. To find out the difference, if any, in measured and estimated GFR in patients with and without AKI.Timepoint: At 28 days (PICU stay)