Confidence in context in obsessive-compulsive disorder.

Completed

Conditions: compulsive disorder
obsessive compulsive disorder
10037173

Registration Number: NL-OMON49752

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Inclusion process: Potential participants are informed about the study and will
receive an information letter. After this, they are contacted by telephone. If
interested to participate, screening for inclusion and exclusion criteria is
performed. In order to be eligible to participate in this study, a subject must
meet all of the following criteria:

OCD subject:
- DSM-5 diagnosis of OCD
- No other psychiatric disorder
- Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 12
- 18-65 years of age
- Willingness and ability to give written informed consent and willingness and
ability to understand, to participate and to comply with the study requirements

HC subject:
- No current psychiatric diagnosis or history of OCD.
- 18-65 years of age
- Willingness and ability to give written informed consent and willingness and
ability to understand, to participate and to comply with the study requirement

Exclusion Criteria

All groups:

- Current major depressive disorder, bipolar disorder, psychotic disorder,
alcohol or substance dependence, or any cognitive disorder as assessed with the
MINI neurological disorders section
- IQ below 80
- Insufficient command of the Dutch language
- recent (<2 weeks) use of psychotropic medication other than naltrexone
(smoking and nicotine dependence is allowed in all groups).
- Endocrinological disorders or regular use of corticosteroids
- Current treatment with SSRIs, tricyclic antidepressant or antipsychotic
medication
- Use of other psychotropic medication or recent use of recreational drugs over
a period of 72 hours prior to each test session, and use of alcohol within the
last 24 hours before each measurement.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Thre are four main study parameters:<br /><br>1) The difference in confidence levels in symptom-related context versus<br /><br>neutral context.<br /><br>2) The coupling between confidence and learning within a volatile environment.<br /><br>3) Metacognitive monitoring: the influence of post-decisional evidence on<br /><br>confidence level updating (i.e.changes of mind).<br /><br>4) Global self-confidence and the relationship to local confidence levels.</p><br>

Secondary Outcome Measures