Stress, habits and attachment in obsessive-compulsive disorder

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 62

Inclusion Criteria

Patients:
- Diagnosis of OCD with obsessions and compulsions assessed with the MINI Neuropsychiatric Interview (MINI)
- Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 12
- 18-65 years of age
- Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements;Controls:
- 18-65 years of age
- Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

Exclusion Criteria

Patients:
- Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI
- Major head trauma or neurological disease, current or in history
- MRI contraindications such as metal implants, claustrophobia, pregnancy
- Self-reported inability or unease to cease smoking for 3 hours prior to testing
- Endocrinological disorders or regular use of corticosteroids
- Current treatment with antipsychotic medication
- Use of other psychotropic medication (apart from SSRI's and tricyclic antidepressants), or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
- Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).;Controls:
- A current or past psychiatric diagnosis as assessed with the MINI
- Major head trauma or neurological disease, current or in history
- MRI contraindications such as metal implants, claustrophobia , pregnancy
- Self-reported inability or unease to cease smoking for 3 hours prior to testing
- Endocrinological disorders or regular use of corticosteroids
- Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement
- Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our main study endpoints include 1.) The balance between goal-directed and<br /><br>habitual responding as measured by the appetitive and avoidance habit task; 2.)<br /><br>The amount of compulsive checking behavior and experienced intolerance of<br /><br>uncertainty as measured in the checking task; 3.) Brain activation patterns as<br /><br>measured with fMRI during these tasks, and an additional emotional face<br /><br>matching task, resting-state condition and DTI; and 4.) The correlation between<br /><br>attachment style as measured with the AAI and ERC with the behavorial and<br /><br>neurobiological study end points of 1-3.</p><br>

Secondary Outcome Measures