Effects of Grape Juice With Breakfast on Glycemia and Cognitive Function in Healthy Adults

Not Applicable

Completed

• Conditions: Glycemic Response; Appetitive Behavior
• Interventions: Other: Low flavonoid beverage; Other: Concord Grape Juice; Other: Low flavonoid low essence beverage

• Registration Number: NCT03409497
• Lead Sponsor: Purdue University

Brief Summary

Assess the impact of 100% grape juice with a meal on postprandial glycemic response and subsequent appetite, food intake and cognitive function.

Detailed Description

Investigators earlier studies and published literature suggest that the phenolic content and strong flavor intensity of 100% Concord grape juice hold potential beneficial effects on blood sugar levels. Investigators aim to better understand the consumption of 100% grape juice with a meal modifies appetite and glycemia acutely and over the day using a 24 hour glucose monitor.

Study Timeline

• Study First Submitted: 2018-01-18
• Study First Submitted QC: 2018-01-23
• Study First Posted: 2018-01-24
• Study Start: 2019-05-17
• Status Verified: 2019-08
• Primary Completion: 2019-10-28
• Study Completion: 2020-06-30
• Last Update Submitted: 2020-11-04
• Last Update Posted: 2020-11-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• BMI between 25.0-34.9 kg/m2
• Willingness to eat all test foods
• Low consumer of tea and coffee, willingness to refrain from both during the 48 hours prior to test days and on the test day
• Fasting blood glucose below 6.1mmol/l via capillary finger-stick blood sample using a SureStep glucometer (Lifescan, Milpitas, CA)

Exclusion Criteria

• Taking medications known to affect glycemia, lipid metabolism or appetite
• Body weight fluctuation of >5kg in the past 3 months
• Taking vitamin or other supplements
• Smokers
• Acute or Chronic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low flavonoid beverage	Low flavonoid beverage	Low flavonoid beverage
Concord Grape Juice	Concord Grape Juice	Concord Grape Juice
Low flavonoid low essence beverage	Low flavonoid low essence beverage	Low flavonoid low essence beverage

Primary Outcome Measures

Name	Time	Method
change in blood glucose over 24 hours	24 hours	samples taken every 5 minutes for 24 hours by a continuous glucose monitor

Secondary Outcome Measures

Name	Time	Method
Appetite	24 hours	Questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly on same day as grape juice intervention

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States