Virtual visual cues to reduce freezing in Parkinson*s disease: an explorative study

Completed

Conditions: Freezing of gait in Parkinson's Disease
10028037

Registration Number: NL-OMON45400

Lead Sponsor: niversiteit Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 35

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:
* age > 18 years
Participants in the PD-FOG group should additionally meet the following criteria:
* idiopathic Parkinson*s Disease fulfilling the UK Brain Bank criteria
* experiencing freezing of gait minimally twice a day. This is defined as a score of 1 on question 1 *have you experienced freezing of gait in the past month* on the New Freezing of Gait Questionnaire (NFOGQ), and at least one freezing of gait episode has been observed by a parkinsonnet-registered physiotherapist, neurologist or one of our clinical researchers.
Healthy controls are age-matched to the PD-FOG participants in the study.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
* Significant cognitive impairments. This is defined as a score on the mini mental state examination (MMSE) equal to or smaller than 24, or a score on the frontal assessment battery (FAB) of equal to or smaller than 13.
* Comorbidities that cause severe gait impairment (e.g. severe arthrosis or neuropathy)
* Inability to lie supine for the duration of the test period
* Inability to walk 150 meters unaided
* Severe visual impairments preventing the participant from using the virtual reality display

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are freezing severity, step time variability<br /><br>variability, modal footstep latency, motor initiation and stopping<br /><br>performance .<br /><br><br /><br>The study parameters are contrasted between:<br /><br>1) Cue responsiveness (during VR foot pedalling and overground walking), and<br /><br>2) The correlation between freezing during overground walking and VR foot<br /><br>pedalling; both uncued and visually cued, and<br /><br>3) Participant category (persons with PD-FOG versus healthy controls)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints are: association of freezing during VR pedalling with<br /><br>subjective FOG severity, and user experience with the paradigm.<br /><br>Other study parameters measured are: age, Hoehn-Yahr-stage, UPDRS part III<br /><br>score, and scores on the mini mental state examination (MMSE) and frontal<br /><br>assessment battery (FAB).</p><br>