The Behavioral and Brain Mechanism of IGD

Not Applicable

Completed

• Conditions: Internet Gaming Disorder

• Registration Number: NCT02550405
• Lead Sponsor: Beijing Normal University

Brief Summary

This project aims to investigate whether anodal tDCS of dlPFC enhances cognitive regulation over craving an emotions.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Primary Completion: 2014-12
• Study First Submitted: 2015-09-10
• Study First Submitted QC: 2015-09-14
• Study First Posted: 2015-09-15
• Study Completion: 2015-12
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-12
• Last Update Posted: 2018-12-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 204

Inclusion Criteria

• Inclusion criteria for IGDs were:

  1. a score of 67 or higher on the CIAS;
  2. engagement in Internet gaming for over 14 hours per week for a minimum of one year; and
  3. reporting of Internet gaming as their primary online activity;

• Inclusion criteria for HCs were:

  1. a score < 60 on the CIAS;
  2. never having spent more than 2 hours per week engaged in Internet gaming

Exclusion Criteria

• for all participants:

  1. current or history of use of illegal substances and gambling;
  2. current or history of psychiatric or neurological illness; and
  3. current use of psychotropic medications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Brain activation during a cue-induced craving task as measured by fMRI	Detecting changes between two different time points (baseline and 6 weeks)	A paradigm using addictive pictures to induce craving
Brain resting state functional connectivity as measured by fMRI	Detecting changes between two different time points (baseline and 6 weeks)	voxel-wise, ROI-wise, and ICA analyses

Secondary Outcome Measures

Name	Time	Method
Brain activation during the Cups task as measured by fMRI	Detecting changes between two different time points (baseline and 6 weeks)	Cups task measuring risky decision-making related to potential gains and losses separately
Brain activation during the mixed gambling task tasks as measured by fMRI	Detecting changes between two different time points (baseline and 6 weeks)	The mix gambling task measuring decision-making related to loss aversion
Craving as measured by brief questionnaire of Internet (gaming) craving	Detecting changes between two different time points (baseline and 6 weeks)	a 8-item 7-point Likert scale
Brain structure as measured by structural MRI	Detecting changes between two different time points (baseline and 6 weeks)	comparing gray matter and white matter differences between individuals with IGD and healthy controls.
Impulsivity as measured by Barratt impulsive scale (BIS-II)	Detecting changes between two different time points (baseline and 6 weeks)	a 30-item 4-point Likert scale
weekly online (gaming) time	Detecting changes between two different time points (baseline and 6 weeks)	self-report,in hours
IGD severity measured by Chen Internet addiction scale	Detecting changes between two different time points (baseline and 6 weeks)	a 26-item 4-point Likert scale

Trial Locations

Locations (1)

State Key Laboratory of Cognitive Neuroscience and Learning; 🇨🇳 Beijing, Beijing, China