Cognitive Training Video Game to Target Subclinical Depressive Symptoms in Youth

Not Applicable

Active, not recruiting

• Conditions: Subclinical Depressive Symptoms; Depression
• Interventions: Device: Computerized cognitive training (CCT) using EndeavorRx

• Registration Number: NCT05697627
• Lead Sponsor: University of Michigan

Brief Summary

The purpose of the study is to determine how cognitive control training (CCT) changes behavior in youth with subclinical depressive symptoms. This research will show what types of behavior changes are important for CCT to help reduce depressive symptoms. In the future, we will use this information to try to improve how we prevent the development of depression, so that it can help more patients.

Detailed Description

The primary study investigator acknowledges contributions from Kate Fitzgerald, Emily Bilek, Christopher Monk, and Adriene Beltz.

Study Timeline

• Study First Submitted: 2023-01-07
• Study First Submitted QC: 2023-01-21
• Study First Posted: 2023-01-26
• Study Start: 2023-05-03
• Status Verified: 2024-07
• Primary Completion: 2024-07-01
• Last Update Submitted: 2024-07-10
• Last Update Posted: 2024-07-11
• Study Completion: 2024-08

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Computerized cognitive training (CCT) using EndeavorRx	Computerized cognitive training (CCT) using EndeavorRx	Exciting, youth-friendly computer game, EndeavorRx engages and trains cognitive control across component processes of attention, response inhibition, shifting and working memory.

Primary Outcome Measures

Name	Time	Method
Change in depressive symptoms as measured by Children's Depression Inventory (CDI)	Baseline, following intervention (approximately 5 weeks)	Self-report, 27 item scale on depressive symptoms. Total scores on this measure range from 0 to 54. Higher scores indicate worse depressive symptoms.
Change in cognitive control scores on several cognitive tasks administered through Inquisit Millisecond. These individual tasks are not part of a composite battery with standard scoring.	Baseline, following intervention (approximately 5 weeks)	There are six different tasks in the non-standardized battery that assess different aspects of cognitive control and emotion regulation. Several tasks (2-3) with the least missingness and/or outliers will be selected to analyze, and task selection will be completed prior to analysis. For measures of reaction time, lower scores indicate better performance. For scores of accuracy, higher scores indicate better performance.

Secondary Outcome Measures

Name	Time	Method
Change in cognitive control scores on several cognitive tasks administered through Inquisit Millisecond. These individual tasks are not part of a composite battery with standard scoring.	Up to 4 months	There are six different tasks in the non-standardized battery that assess different aspects of cognitive control and emotion regulation. Several tasks (2-3) with the least missingness and/or outliers will be selected to analyze, and task selection will be completed prior to analysis. For measures of reaction time, lower scores indicate better performance. For scores of accuracy, higher scores indicate better performance.
Depressive symptoms as measured by CDI	Up to 4 months	Self-report, 27 item scale on depressive symptoms. Total scores on this measure range from 0 to 54. Higher scores indicate worse depressive symptoms.

Trial Locations

Locations (1)

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States