The Prognostic Value of Biomarkers in Adult Moderate to Severe Traumatic Brain Injury Patients

Not Applicable

Recruiting

• Conditions: Diseases of the nervous system

• Registration Number: KCT0004811
• Lead Sponsor: Asan Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 18 May 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

1.Age =18 years and = 80 years
2.Acute traumatic brain injury; Diffuse axonal injury, subarachnoid hemorrhage (non-aneurysmal rupture); intracranial or intraventricular hemorrhage, subdural hematoma, epidural hematoma (either primary or anticoagulants-associated)
3.Moderate to severe traumatic brain injury (TBI): Glasgow Coma Scale (GCS) of 3 – 12

Exclusion Criteria

1.Post-anoxic coma; status epilepticus without underlying brain injury; central nervous system (CNS) infections (community-acquired; hospital-acquired; ventriculitis; post-operative)
2.Known previous neurological disease, causing significant cognitive and/or motor handicap
3.Hemorrhage due to arterio-venous malformation (AVM), cavernous malformation (CM), cerebral aneurysm rupture or brain tumor
4.Hypertensive ICH or IVH
5.Pregnancy or Nephrotic syndrome diagnosed patient
6.DNR (do not resuscitate) orders

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glasgow Coma Scale;Modified Rankin Scale;Korean mini mental status (K-MMSE);Korean Montreal Cognitive Assessment [K-MoCA];Center for Epidemiologic Studies – Depression Scale [CES-D]

Secondary Outcome Measures

Name	Time	Method
Days of ICU stay;Need for tracheostomy