Multicenter Comparative Study of the Activity of the Medial Prefrontal Cortex in Vulnerability to Depression
- Conditions
- Major Depression
- Registration Number
- NCT02171923
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
To examine whether the medial prefrontal cortex displays an increased activity during self-referential processing among remitted depressed patients compared to healthy controls
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 77
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method BOLD signal in the medial prefrontal cortex 18 month Each subject will have a standardized psychometric assessment (BDI-21, MADRS, STAI, RRS) in a Siemens 3T Trio for collecting voxel BOLD signal (Blood-Oxygen-Level Dependent). For each subject and each voxel, a coefficient beta relative activation will be obtained with a general linear model using the timing of presentation of stimuli and the expected signal to model the measured hemodynamic BOLD response. A main effect of condition (personal versus general) will be sought to determine the peak activation within the dorsal CMPF (defined region of interest using the Pickatlas software). The primary endpoint will be the beta coefficient on the level of activation of a sphere 10 mm in diameter centered on the peak.
- Secondary Outcome Measures
Name Time Method depression relapse 1 year The presence (MINI) and intensity (BDI) for possible depressive relapse will be sought from the attending psychiatrist and during telephone interviews at 6 and 12 months.
Trial Locations
- Locations (1)
URC - HEGP, 20 rue Leblanc
🇫🇷Paris, France