Does Lowering Homocysteine slow the rate of memory loss in healthy older people?

Completed

• Conditions: ormal Ageing; Neurological - Studies of normal psychology, cognitive function and behaviour; Normal Ageing

• Registration Number: ACTRN12605000030673
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-07-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 260

Inclusion Criteria

Total plasma homocysteine concentration >= 13 [micro]mol/L; not taking supplementary folic acid or vitamins B-12 or B-6; no prior stroke; not diabetic; no established dementia; not taking folate inhibiting medications (antiepileptics, oral hypoglycaemics, treatment for depression); have normal renal function (creatinine clearance <133 [micro]mol/L in men and < 115 [micro]mol/L in women); availble for at least 2 years.

Exclusion Criteria

No exclusion criteria

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine if the rate in slowing of cognitive perfomance associated with normal ageing can be slowed by lowering homocysteine concentrations when measured by a range of tests of cognition[At 1 and 2 years of intervention]

Secondary Outcome Measures

Name	Time	Method
To determine if the primary outcome measure is influenced by genotype, older age, higher starting homocysteine concentration, mood state.[After 1 and 2 years of intervention.]