SK-1401 (rhGM-CSF agent for inhalation) GM-CSF Inhalation Pharmacokinetic study (NTU Trial)
- Conditions
- autoimmune pulmonary alveolar proteinosis
- Registration Number
- JPRN-UMIN000022116
- Lead Sponsor
- iigata University Medical and Dental Hospital Bioscience Medical Reseach Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 14
Not provided
1. WBC of 12000/ul or more 2. Fever of 38 degree celsius or more 3. History of malignant disease within recent 5 years (not applied to the treatedcases of local basal cell carcinoma) 4. Complication of severe cardiovascular diseases including congestive heart failure, angina pectoris, hemorrhagic tendency, etc. 5. Complication of respiratory diseases such as pulmonary infectious disease(incl. pulmonary tuberculosis), interstitial pneumonitis, lung fibrosis or bronchiectasis, in which the evaluations of safety of GM-CSF therapy are considered to be difficult. 6. History or complication of infectious diseases which require systemic administration of antibiotics, antifungal or antiviral agents within recent 2 weeks. 7. liver dysfunction (CTCAE Grade 1 or higher) 8. renal dysfunction (CTCAE Grade 1 or higher) 9. Previous experience of severe and unexplained adverse events during aerosol delivery of any kind of medicinal product 10. Positive for HIV-Ab, HBs-Ag, HCV-Ab, STS or TPHA 11. allergic to GM-CSF. 12. addicted to illegal drugs 13. Participation to other clinical trials within 12 weeks before registration. 14. smoking within 5 years 15.cannot follow the procedure defined in this protocol aPAP patient must exclude the following 16. Pregnant or possibly pregnant women, lactating women, and women who desire to become pregnant during the study period 17. Patients who have been treated with whole-lung lavage, repeated segmental-lung lavage, GM-CSF or rituximab within 6 months before the start of the study. 18. taking other inhalation. Healthy volunteer must exclude the following 19.taking any prescribed medicines.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluate PK (0.5, 1, 2, 4, 8, 12 and 24 hours after inhalation).
- Secondary Outcome Measures
Name Time Method Safety