NCT02139410已完成不适用
Insulin Like Growth Factor 1 and Risks of Sarcopenia and Mortality in Patients With Cognitive Impairment
University of Roma La Sapienza2 个研究点 分布在 1 个国家目标入组 589 人开始时间: 2008年6月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 589
- 试验地点
- 2
- 主要终点
- IGF-1 reduction in patients with sarcopenia
研究概览
简要总结
Insulin-like growth factor 1 (IGF)-1 is an important neuromyotrophic hormone. Disregulation of this hormone has been reported to influence the genesis of cognitive impairment and dementia in the elderly patients. We analyzed the possible link between IGF-1 and risk of Sarcopenia and Mortality in a cohort of elder patients with cognitive impairment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of cognitive impairment (MMSE < 24)
- •Age > 65 ys
排除标准
- •Diagnosis of pancreatic disorders
- •Diagnosis of acromegaly
- •Diagnosis of GH-related disorders
- •Recent bone fractures or immobility before the enrollment (3 months)
结局指标
主要结局
IGF-1 reduction in patients with sarcopenia
时间窗: baseline, 24 months, 48 months
IGF-1 reduction could be linked to sarcopenia in patients with cognitive impairment
次要结局
- IGF-1 reduction and mortality in patients with cognitive impairment(baseline, 24 months, 48 months)
研究者
Vincenzo Gianturco
MD
University of Roma La Sapienza
研究点 (2)
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