Comparison of the ocular microbiota on ocular surface between SJS/TEN patients and healthy subjects

Not Applicable

Completed

• Conditions: Ocular microbiome in chronic SJS/TEN patients and healthy subjects; Ocular microbiome; Ocular microbiota; Microbial flora; Stevens- Johnson Syndrome; Toxic epidermal necrolysis; Next generation sequencing analysis

• Registration Number: TCTR20190505001
• Lead Sponsor: Ratchadapisek Sompotch Research Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-02-28
• Study Start: 2019-05-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

SJS/TEN group
Chronic SJS/TEN patients who are able to come for check-up at the out-patient
department of King Chulalongkorn Memorial Hospital

Healthy group
Subjects without chronic ocular allergy, inflammation or any other ocular surface diseases

Exclusion Criteria

Participants with these conditions who:
oreceived topical antibiotics within the past 4 weeks.
ohad acute ocular or periocular infection within the past 4 weeks.
ounderwent ocular or periocular surgery within the past 3 months.
oare using contact lens, or had punctal plug performed previously.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ocular microbiome of chronic SJS/TEN patients and heathly subjects 3 months Next-Generation Sequencing analysis

Secondary Outcome Measures

Name	Time	Method
microbial detection from conventional culture methods in SJS/TEN patients and healthy subjects 3 months conventional culture methods