Verbeterde diagnostiek bij Staphylococcus aureus bacteriëmie
- Conditions
- ENG: Staphylococcus aureus bacteraemia, sepsis, endocarditis, infection. NL: Staphylococcus aureus, staphylokokken, endocarditis, infectie, sepsis, bloedvergiftiging.
- Registration Number
- NL-OMON27100
- Lead Sponsor
- Academic Medical Center, Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 450
Inclusion Criteria
> Adult (aged ≥18yr old) patients with SAB, admitted to the hospital
> Written informed consent by patient or legal representative
Exclusion Criteria
Main cohort study:
> no exclusion criteria
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main cohort study: <br /><br>1. Presence or absence of infective endocarditis and/or complicated SAB, as classified by study adjudication committee at the end of the study based on all clinical information up to 90 days after discharge. <br /><br /><br><br>cCT sub-study: <br /><br>1. Diagnostic accuracy of cardiac CT for the diagnosis of endocarditis in patients with SAB. <br /><br /><br><br>qPCR sub-study: <br /><br>1. Diagnostic accuracy of qPCR for the diagnosis of complicated SAB and SA-IE bacteraemia in patients with SAB. Biobank sub-study: <br /><br /><br><br>1. The diagnostic and prognostic value of host response biomarkers during antimicrobial therapy for the diagnosis of complicated SAB and SA-IE
- Secondary Outcome Measures
Name Time Method