Improved Diagnostic Strategies in Staphylococcus aureus bacteraemia
Completed
- Conditions
- Endocarditissepsis1004697310004018
- Registration Number
- NL-OMON49374
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 526
Inclusion Criteria
Positive bloodculture with Staphylococcus aureus
Exclusion Criteria
For the main study and the qPCR and Biobank sub-studies: none., For the cCT
substudy: eGFR <45ml/min, pregnancy, female <30 years, inability to provide
informed consent, life-expectancy <4 weeks, hemodynamic instability or
respiratory failure.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main cohort study:<br /><br>1. Presence or absence of infective endocarditis and/or complicated SAB, as<br /><br>classified by study adjudication committee at the end of the study based on all<br /><br>clinical information up to 90 days after discharge.<br /><br><br /><br>cCT sub-study:<br /><br>1. Diagnostic accuracy of cardiac CT for the diagnosis of endocarditis in<br /><br>patients with SAB.<br /><br><br /><br>qPCR sub-study:<br /><br>1. Diagnostic accuracy of qPCR for the diagnosis of complicated SAB and SA-IE<br /><br>bacteraemia in patients with SAB.<br /><br><br /><br>Biobank sub-study:<br /><br>1. The diagnostic and prognostic value of host response biomarkers during<br /><br>antimicrobial therapy for the diagnosis of complicated SAB and SA-IE </p><br>
- Secondary Outcome Measures
Name Time Method