NMES During the Day and Prior to Sleep

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Procedure: Dietary protein plus NMES prior to sleep; Procedure: Dietary protein plus NMES during the day

• Registration Number: NCT02253329
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and prior to sleep

Detailed Description

In the present study, the effect of a bolus of intrinsically labeled milk directly after an hour of one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and immediately prior to sleep

Study Timeline

• Study First Submitted: 2014-09-29
• Study First Submitted QC: 2014-09-29
• Study First Posted: 2014-10-01
• Study Start: 2015-01
• Status Verified: 2015-05
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Last Update Submitted: 2015-05-20
• Last Update Posted: 2015-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 16

Inclusion Criteria

• Age 65-85 years
• Male
• 18.5 ≤ BMI ≤ 30.0

Exclusion Criteria

• Type II diabetes
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
• Use of anticoagulants, blood diseases, allergy for lidocaine
• Use of NSAIDs (non-steroidal anti-inflammatory drugs) and acetylsalicylic acid
• Patients suffering from PKU (Phenylketonuria)
• Presence of implantable cardioverter defibrillator and/or pacemaker
• Performed regular resistance type exercise in the past 6 months
• Use of any tools to assist during walking (cane/ crutches/ walker)
• (Partial) foot/ leg amputation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treatment prior to sleep	Dietary protein plus NMES prior to sleep	Protein ingestion directly after one-legged NMES, directly prior to sleep
Treatment during the day	Dietary protein plus NMES during the day	Neuromuscular electrical stimulation after a protein bolus, performed during the day

Primary Outcome Measures

Name	Time	Method
Incorporation of stable isotope amino acids into skeletal muscle tissue	4-8 hours in the postprandial phase

Secondary Outcome Measures

Name	Time	Method
Plasma amino acid enrichment	4-8 hours in the postprandial phase

Trial Locations

Locations (1)

Maastricht University Medical Centre +; 🇳🇱 Maastricht, Netherlands