Exogenous Ketone Supplementation and Exercise Performance
- Conditions
- KetonemiaKetosis
- Interventions
- Behavioral: 20 km time trialBehavioral: Wingate testDietary Supplement: Ketone/CaffeineDietary Supplement: Water PlaceboDietary Supplement: Ketone
- Registration Number
- NCT03895892
- Lead Sponsor
- Western University, Canada
- Brief Summary
20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo. Participants will complete the protocol three times and the treatment order will be systematically rotated to avoid any order effect. The three main trials will be separated by at least 1 week. After providing the corresponding treatment, participants will be given 30 minutes and after, they will perform a standardized 10-minute warm-up, followed by the 20 km time trial and a 30-second all-out Wingate test.
- Detailed Description
Some researchers support that a state of ketosis, reached through the use of ketogenic diet, has the potential to improve athletic. To attain such state, individuals must restrict carbohydrate intake to a maximum of 50g/ day or 10% while keeping protein intake moderate. One of the biggest challenges to achieve and maintain ketosis is complying with the diet due to its restrictive nature. Consequently, manufacturers have developed supplements that can induce a state of ketosis acutely (\~1 hour). Unfortunately, there is very little evidence supporting the use of these supplements to enhance athletic performance. Hyperketonemia (blood ketone concentration \> 0.2 Mm) seems to elevate the rate of utilization of ketone bodies. These changes in substrate utilization may allow athletes to preserve, something that would be advantageous for exercise performance. Ketone salts have been shown to elevate the concentration of ketones in blood and as such they may allow the body benefit from the apparent sparing of carbohydrates. Manufacturers now provide ketones salts combined with other ingredients such as caffeine. However it is unknown whether or not the addition of these ingredients has any positive or negative effect on athletic performance. Caffeine alone has been shown to improve athletic performance in several studies. Therefore, the purpose of this study is to compare the effectiveness of a caffeine free ketone salt supplement vs a caffeinated ketone salt supplement and their effects on a 20km time trial and a 30 second all-out Wingate test.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Healthy male and female recreationally active individuals
- aged 15-35 years
- non regular caffeine users.
- Smoker
- Taking part in other research
- Sedentary
- For women, if they are pregnant or become pregnant during the study
- Injury limiting exercise ability.
- Have symptoms or take medication for respiratory disease
- Have symptoms or take medication for cardiovascular disease
- Have symptoms or take mediation for neuromuscular disease
- Use heart rate or blood pressure medications
- Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Water Placebo Wingate test Placebo flavored drink similar to treatments but with no energy will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Experimental 2 Ketone/Caffeine Ketone salts/caffeine supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Water Placebo Water Placebo Placebo flavored drink similar to treatments but with no energy will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Experimental 1 20 km time trial Ketone salts supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Experimental 1 Ketone Ketone salts supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Water Placebo 20 km time trial Placebo flavored drink similar to treatments but with no energy will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Experimental 1 Wingate test Ketone salts supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Experimental 2 Wingate test Ketone salts/caffeine supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test Experimental 2 20 km time trial Ketone salts/caffeine supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test
- Primary Outcome Measures
Name Time Method 20 km time trial 40 minutes participants will ride for 20 km on a stationary bike and time to complete distance will be measured.
Wingate test 30 seconds participants will perform a ver short all-out effort on a stationary bike. peak power output and fatigue index will be measured.
- Secondary Outcome Measures
Name Time Method Rates of perceived exertion (RPE) 1 hour RPE will be measured using Borg's scale (1= low - 10= high).
Blood Ketone 1 hour blood ketones will be measured using ketone meter
Blood Lactate 1 hour blood lactate will be measured using lactate meter
Trial Locations
- Locations (1)
Exercise Nutrition Laboratory (Western University)
🇨🇦London, Ontario, Canada