Prevalence of HPV-associated Eye Infection and Cytokine Levels in Tears From Patients Diagnosed With Pterygium
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 141
- 试验地点
- 1
- 主要终点
- HPV prevalence
研究概览
简要总结
Prevalence of HPV-associated eye infection and cytokine levels in tears from patients diagnosed with pterygium
详细描述
The main purpose of this study is to evaluate the prevalence of HPV infection in primary and recurrent pterygium and the association of HPV types collecting from conjunctiva swab and urine. The second purpose is to compare a quantity of cytokines including IL-6, IL-18 and growth factor including VEGF found in tears of patients with primary and recurrent pterygium to participants with free of ocular disease Primary hypothesis
- The prevalence of HPV infection in primary pterygium is difference with prevalence in recurrent pterygium patients.
Secondary hypothesis
- Ocular HPV infection has association with HPV genitalia infection.
- Tears cytokine and growth factor level (IL-6, IL-18 and VEGF) are higher in pterygium HPV infection than non-HPV infection and also more than normal population
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age above 18 years old
- •presence of pterygium invading the cornea
排除标准
- •Other ocular inflammation that could affect the results of the study (such as conjunctivitis, keratitis, conjunctival tumor, etc) or would preclude the enrollment for safety reasons
- •Participant without ocular disease Inclusion criteria
- •Age above 18 years old Exclusion criteria
- •Presence of any ocular inflammation diseases
结局指标
主要结局
HPV prevalence
时间窗: 1 hour per participants which is on a day for collecting sample
1. To compare HPV prevalence in subjects with primary pterygium and with recurrent pterygium
次要结局
- cytokine IL-6, IL-18 and VEGF levels(1 hour per participants which is on a day for collecting sample)
- HPV autoinoculation(1 hour per participants which is on a day for collecting sample)
研究者
Ngamjit Kasetsuwan
Associate professor
Chulalongkorn University