Comparison of two drugs on sore throat after intubation.

Phase 3

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/06/034027

Brief Summary

100 patients of 18-65 yrs age,posted for surgeries requiring general anaesthesia with endotracheal intubation under ASA1to ASA3,for surgeries less than 3hrs will be given one of the two study drugs Magnesium Sulphate 225 mg or Dexmedetomidine0.5 mg by nebulization.Standardized General Anaesthesia with intra-operative vitals will be recorded.

Post operative rescue analgesic given at 0,1,2,6,12 and 24 hrs.

All adverse events as in allergic reaction,muscle weakness,prolonged sedation,and diarrhoea will be recorded.

The incidence of sore throat in both groups measured and the best drug is derived by statistical methods.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-04-06
• Study Start: 2021-06-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• i) Informed Written consent ii) Age between 18-65 years. iii) Patients undergoing surgery under general anesthesia. iv) ASA.
• II iv) Duration of surgery within 3 hrs.

Exclusion Criteria

• 1.Emergency surgeries 2.Patients undergoing Tonsil,thyroid and other throat surgeries.
• 3.Surgeries more than 3 hrs duration.
• 4.Allergy to study drugs – to prevent anaphylaxis 5.Patients on pain medication,Calcium channel blockers,Quinolones And tetracyclines.
• 7.Chronic renal failure and pre existing myopathy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparing efficacy of Magnesium sulphate and Dexmedetomidine nebulization for postoperative sore throat after general anaesthesia with endotracheal intubation	0,2,4,8,16 and 24 hrs after general anaesthesia

Secondary Outcome Measures

Name	Time	Method
To compare the side effects and adverse events of Magnesium Sulphate and Dexmedetomidine nebulization.	0,2,4,8,16 and 24 hrs after General anaesthesia.

Trial Locations

Locations (1)

ESIC Medical college and PGIMSR; 🇮🇳 Chennai, TAMIL NADU, India

ESIC Medical college and PGIMSR

🇮🇳Chennai, TAMIL NADU, India

Dr Shirishkumar chavan

Principal investigator

9947098333

drshirishchavan@gmail.com