Treatment of Peri-calcification Edema in Neurocysticercosis (NCC)
- Registration Number
- NCT02945527
- Lead Sponsor
- Universidad Peruana Cayetano Heredia
- Brief Summary
Three-arm open, randomized comparative study of acetazolamide, dexamethasone, or no additional treatment to evaluate decrease in peri-calcification edema in neurocysticercosis
- Detailed Description
This study will evaluate 24 patients with calcified NCC and edema in three treatment arms to compare the reduction in edema volume
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 4
Inclusion Criteria
- Calcified NCC
- Perilesional edema on CT or MRI
- Normal lab values
Exclusion Criteria
- Viable neurocysticercosis
- Status epilepticus
- Symptomatic intracranial hypertension
- Tuberculosis
- More than 7 days after seizure
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dexamethasone Dexamethasone 8 mg p.o. divided in three daily daily doses, for 2 days followed by gradual tapering Acetazolamide Acetazolamide 750 mg acetazolamide p.o. divided in three dily doses, for 10 days
- Primary Outcome Measures
Name Time Method Decrease in Volume of Perilesional Edema Between Baseline and Day 4 Baseline to Day 4 MRI extension of edema
- Secondary Outcome Measures
Name Time Method Decrease in Volume of Perilesional Edema Between Baseline and Day 8 Baseline to Day 8 MRI extension of edema
Decrease in Volume of Perilesional Edema Between Baseline and Day 30 Baseline to Day 30 MRI extension of edema
Trial Locations
- Locations (1)
Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas
🇵🇪Lima, Peru