Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of GGO LUAD Via WMS (ECTOP-1011)

Completed

• Conditions: Adenocarcinoma of Lung

• Registration Number: NCT05252676
• Lead Sponsor: Fudan University

Brief Summary

This study is one of the Eastern Cooperative Thoracic Oncology Projects (ECTOP-1011). It aims to evaluate the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma via whole-mount section.

Detailed Description

The pathological lepidic growth pattern was believed to relate to the ground-glass component, whereas invasive adenocarcinoma patterns relate to the solid component. However, the solid components might be fibrosis rather tumor; and previous studies demonstrated the ground-glass components might be invasive lesions. Therefore, it is of considerable significance to establish the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma.

Study Timeline

• Study Start: 2021-10-01
• Study First Submitted: 2022-02-13
• Study First Submitted QC: 2022-02-13
• Study First Posted: 2022-02-23
• Primary Completion: 2022-08-31
• Study Completion: 2022-12-01
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-19
• Last Update Posted: 2023-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 103

Inclusion Criteria

• Ground glass opacity featured lung nodule diagnosed by thin-section computed tomography(TSCT)
• Pre-operation clinical IA stage
• Pulmonary lobectomy or segmentectomy
• Provision of informed consent

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Exclusion Criteria

• Postoperative diagnosis of non-adenocarcinoma or mucinous adenocarcinoma
• The surgical specimens fail to satisfy requirement of inflation and formalin fixation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of correlations between radiologic features and pathologic subtypes	about 14 days	Evaluation of correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma

Secondary Outcome Measures

Name	Time	Method
Specificity, Sensitivity, and Repeatability	about 14 days	The specificity, sensitivity, and repeatability of invasiveness diagnosis based on the Whole-Mount Section

Trial Locations

Locations (1)

Fudan University Cancer Center; 🇨🇳 Shanghai, Shanghai, China