Genetic Basis of Odor Discrimination

Completed

• Conditions: Non-smokers

• Registration Number: NCT01039935
• Lead Sponsor: Rockefeller University

Brief Summary

Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Study First Submitted: 2009-12-23
• Study First Submitted QC: 2009-12-24
• Study First Posted: 2009-12-25
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Status Verified: 2012-09
• Last Update Submitted: 2012-09-05
• Last Update Posted: 2012-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 512

Inclusion Criteria

1. Age 18-50
2. Current non-smokers

Exclusion Criteria

1. Current smokers
2. Allergy to fragrances or smells of any kind
3. Active head cold, upper respiratory infection, or seasonal nasal allergies
4. History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal.
5. Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors	3 years

Secondary Outcome Measures

Name	Time	Method
concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors	3 years

Trial Locations

Locations (1)

The Rockefeller University; 🇺🇸 New York, New York, United States