Plasma connective tissue growth factor (CTGF) as a surrogate biomarker in asthma.
Not Applicable
- Conditions
- asthma
- Registration Number
- JPRN-UMIN000013081
- Lead Sponsor
- Hamamatsu University School of Medicine
- Brief Summary
Plasma CTGF levels were higher in patients with asthma than healthy volunteers. Plasma CTGF levels showed significantly negative correlations with forced expiratory volume in 1 second (FEV1), FEV1 percentage of the predicted value (%pred), forced expiratory flow at 50% of the forced vital capacity (FEF50), FEF50 %pred, FEF75, and FEF75 %pred, parameters reflecting the degree of airway obstruction, in patients with asthma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1) treatment with oral or intravenous corticosteroids in the previous 4 weeks, 2) having a smoking history more than 10 pack-years, 3) having other pulmonary diseases including chronic obstructive pulmonary disease.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Correlations between plasma CTGF levels and airway obstruction in patients with asthma.
- Secondary Outcome Measures
Name Time Method Correlations between plasma CTGF levels and other clinical parameters in patients with asthma.