Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia
- Conditions
- Community-acquired Pneumonia
- Interventions
- Registration Number
- NCT07164131
- Lead Sponsor
- Mayo Clinic
- Brief Summary
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 1120
• All adult patients (>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.
- High clinical suspicion for Legionella pneumonia
- Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
- Antibiotics not for CAP
- Pregnant women (based on clinical assessment as part of standard of care)
- Severe CAP as defined by the ATS/IDSA criteria
- Corrected QT prolongation (> 440 ms in men and > 460 ms in women)
- Receiving a different antibiotic (e.g quinolones)
- Admission > 24 hours
- Known to be a prisoner
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Doxycycline group Doxycycline Subjects hospitalized for community acquired pneumonia will receive standard of care treatment with Doxycycline Azithromycin group Azithromycin Subjects hospitalized for community acquired pneumonia will receive standard of care treatment with Azithromycin
- Primary Outcome Measures
Name Time Method Hospital-free days 28 days Number of days subject remained out of hospital
- Secondary Outcome Measures
Name Time Method Oxygen-free days 28 days Number of days subject does not require new supplemental oxygen use. Oxygen-free days will be set as 0 for patients who died during the stay or had a length of stay of ≥28 days
180-day mortality 180 days Defined as mortality at 180 days after discharge
Need for advanced respiratory support or in-hospital mortality Up to 28 days Defined as a composite of need for advanced respiratory support or mortality during hospitalization. Need for advanced respiratory support would include need for high flow nasal cannula, non-invasive positive pressure ventilation, and invasive ventilation in patients not requiring this at baseline.
Trial Locations
- Locations (5)
Mayo Clinic in Arizona
🇺🇸Scottsdale, Arizona, United States
Mayo Clinic in Florida
🇺🇸Jacksonville, Florida, United States
Mayo Clinic Health System-Mankato
🇺🇸Mankato, Minnesota, United States
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States
Mayo Clinic Health System-La Crosse
🇺🇸La Crosse, Wisconsin, United States
Mayo Clinic in Arizona🇺🇸Scottsdale, Arizona, United States