Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome
- Conditions
- ObeseHealthyBariatric Surgery Candidate
- Registration Number
- NCT05408728
- Lead Sponsor
- Mayo Clinic
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria:<br><br> - Obese patients (BMI = 30) scheduled for BS undergoing standard of care screening<br> EGD, or lean BS-naïve individuals (BMI = 25) subjected to EGD for routine clinical<br> indications as part of standard care.<br><br>Exclusion Criteria:<br><br> - Adults unable to consent, including non-English speakers.<br><br> - Pregnant women because endoscopy is a risk factor. All patients of childbearing age<br> undergo history as well as urine pregnancy test as a standard of care prior to<br> undergoing endoscopy as the procedure is performed under anesthesia.<br><br> - Prisoners.<br><br> - Subjects with preexisting conditions (e.g., bleeding at the time of the procedure,<br> suspected perforation during the standard-of-care procedure) will be excluded from<br> the study at the time of the endoscopy.<br><br> - Have a contraindication to endoscopy.<br><br> - A history of surgery on the stomach or small intestine.<br><br> - Type 1 diabetes (clinical diagnosis and/or positive glutamic acid decarboxylase<br> antibodies).<br><br> - Using weight loss medications.<br><br> - Active malignancy within the last 5 years.
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of obese patients with altered dietary sugar hyper-absorptive phenotype after bariatric surgery
- Secondary Outcome Measures
Name Time Method Epigenetic changes measured in the intestinal mucosa of obese patients with dietary sugar hyper-absorptive phenotype after bariatric surgery