Preoperative Oral Carbohydrate Treatment Minimizes Insulin Resistance

Not Applicable

• Conditions: Insulin Resistance

• Registration Number: NCT03658564
• Lead Sponsor: The Second Affiliated Hospital of Dalian Medical University

Brief Summary

Insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Detailed Description

Insulin resistance is a positive protective reaction against surgery . As a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. However, this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.

Study Timeline

• Study First Submitted: 2018-05-19
• Status Verified: 2018-09
• Study First Submitted QC: 2018-09-04
• Study First Posted: 2018-09-05
• Study Start: 2018-09-30
• Last Update Submitted: 2018-10-08
• Last Update Posted: 2018-10-10
• Primary Completion: 2018-12
• Study Completion: 2019-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery

Exclusion Criteria

• Weight loss greater than 10 per cent during the previous 6 months
• Renal insufficiency (creatinine, > 3 mg/dl; hemodialysis)
• Hepatic insufficiency (Child-Pugh class, ≥ B)
• Gastro-oesophageal reflux disease
• Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
VAS	1 day (preoperative period)	Preoperative general well-beings before assessed with the visual analogue scale (VAS).

Secondary Outcome Measures

Name	Time	Method
HOMA	perioperative period)	Preoperative insulin resistance before and immediately after the surgery assessed with the homeostasis model assessment (HOMA)

Trial Locations

Locations (1)

The Second Hospital of Dalian Medical University; 🇨🇳 Dalian, Liaoning, China