Preoperative Oral Carbohydrate Treatment in Diabetes Patients: A Randomized, Double-blind Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- VAS
研究概览
简要总结
Insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.
详细描述
Insulin resistance is a positive protective reaction against surgery . As a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. However, this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery
排除标准
- •Weight loss greater than 10 per cent during the previous 6 months
- •Renal insufficiency (creatinine, > 3 mg/dl; hemodialysis)
- •Hepatic insufficiency (Child-Pugh class, ≥ B)
- •Gastro-oesophageal reflux disease
- •Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate
研究组 & 干预措施
Oral carbohydrate
fast from midnight the night before surgery, and patients consume 400 ml Preoperative oral carbohydrate preOp®(12.5% carbohydrates, 0.5%kcal/ml, 240 mOsm, pH 4.9, Nutricia Zoetermeer, the Netherlands) 3 hours prior to induction of anesthesia and finished the ingestion within 20 minutes.
干预措施: Preoperative Oral Carbohydrate Drink (Dietary Supplement)
Fasting
fast from midnight the night before surgery, and no preoperative oral carbohydrate loading
结局指标
主要结局
VAS
时间窗: 1 day (preoperative period)
Preoperative general well-beings before assessed with the visual analogue scale (VAS).
次要结局
- HOMA(perioperative period))