Comparisom of Liquid Nitrogen and Vitamin D3 in The Treatment of Cutaneous Warts

Phase 1

Completed

• Conditions: Cutaneous Warts
• Interventions: Drug: intralesional vitamin D3; Drug: liq nitrogen

• Registration Number: NCT05739786
• Lead Sponsor: Combined Military Hospital Abbottabad

Brief Summary

A total of 60 female patients (30 patients in each group) with cutaneious warts diagnosed by a consultant dermatologist on physical examination were included in this study.

In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) while patients in Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness in both groups was ascertained in terms of \> 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-11
• Primary Completion: 2022-11-11
• Study Completion: 2022-11-11
• Study First Submitted: 2023-01-18
• Status Verified: 2023-02
• Study First Submitted QC: 2023-02-13
• Last Update Submitted: 2023-02-13
• Study First Posted: 2023-02-22
• Last Update Posted: 2023-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patient of cutaneous warts presented in dermatology department.

Exclusion Criteria

• Immunosuppressed patients
• chronic skin diseases like eczema or autoimmune disease
• diabetes mellitus
• cold sensitivity , skin allergies
• pregnancy, and lactation
• periungual warts

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group B intralesional Vit D3	intralesional vitamin D3	intralesional Vit D3 Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness was ascertained in terms of \> 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.
Group A liquid nitrogen	liq nitrogen	liquid nitrogen In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) for 3 sessions at every 3 weeks interval. Effectiveness in was ascertained in terms of \> 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.

Primary Outcome Measures

Name	Time	Method
Effectiveness of liquid nitrogen and intralesional vitamin D3 in treatment of cutaneous warts	9 weeks	For 2nd Article: A total of 60 female patients (30 patients in each group) with cutaneous warts diagnosed by a consultant dermatologist on physical examination were included in this study.; In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) while patients in Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness in both groups was ascertained in terms of \> 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.Total duration of therapy for each patient will be 9 weeks after "recurrence and remission"

Trial Locations

Locations (1)

Sara Ilyas; 🇵🇰 Abbottābād, Kpk, Pakistan