Treatment of gum recession using grafts prepared from blood

Completed

• Conditions: Gingival recession,

• Registration Number: CTRI/2021/12/038682
• Lead Sponsor: Dr Anupama Tadepalli

Brief Summary

Gingival recession is the exposure of root surface due to displacement of gingival margin apical to the cementoenamel junction. Vigorous tooth brushing (most common causative factor) high frenal attachments, plaque, calculus and iatrogenic factors are responsible for the recession. The subepithelial connective tissue graft along with coronally advanced flap technique is the gold standard (Chambrone et al., 2008) (Cairo et al., 2014) and it is the most predictable technique for root coverage. Harvesting connective tissue has inherent limitations like second surgical site and donor site morbidity (pain, discomfort and difficulty during eating, swallowing). Additionally procuring sufficient connective tissue graft material for treating multiple gingival recessions is technically challenging. Recent modifications  of  the  PRF preparation   procedure (2700rpm for 12min 708G)  have  led  to  the development of advanced  platelet  rich  fibrin 1500 rpm 14min 200G (A-PRF)  and 1500 rpm 8min 200G(A-PRF+) which uses  lower G forces proven to have greater number of platelets and growth factor content. Their application in recession management was not documented. This study proposes to investigate and compare clinical efficacy of A-PRF and A-PRF+ membranes in management of gingival recession defects along with coronally advanced flap.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-27
• Study Completion: 2023-10-07
• Last Update Posted: 2024-02-07

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with gingival recession defects in maxillary anteriors and premolars 2.
• Minimum recession ≥ 2mm 3.
• Systematically healthy patients.

Exclusion Criteria

• Recession sites with probing depth ≥ 4mm and mobile teeth 2.
• Teeth with prosthetic restorations 3.
• Anemic patients 4.
• Platelet disorders 5.
• Pregnant and lactating women 8.
• Patients with poor oral hygiene 9.
• Systemic condition /disease/any medication influencing the periodontal therapy and disease.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess and compare the changes in Recession height (RH) before and after therapy with in and between groups	Baseline, 3 months, 6 months

Secondary Outcome Measures

Name	Time	Method
To compare changes in	1.Gingival biotype

Trial Locations

Locations (1)

SRM dental hospital; 🇮🇳 Chennai, TAMIL NADU, India

SRM dental hospital

🇮🇳Chennai, TAMIL NADU, India

Dr Anupama Tadepalli

Principal investigator

9677065517

anupamamds@gmail.com