Effect of spironolactone on ischemia reperfusion injury in renal transplant recipients

Completed

• Conditions: Circulatory System; Ischemia reperfusion injury

• Registration Number: ISRCTN01577227
• Lead Sponsor: Mexican Council of Science and Technology (Consejo Nacional de Ciencia y Tecnología CONACyT) (Mexico)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Age of 18 years or older, male and female
2. Receipt of a live-donor kidney

Exclusion Criteria

1. Multi-organ transplant
2. Deceased-donor kidney
3. Induction with thymoglobuline

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction of urinary biomarkers of kidney injury [ Heat shock protein 72 (HsP72), Interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1)] at baseline, day 1, and 5 post transplantation.

Secondary Outcome Measures

Name	Time	Method
1. Reduction of oxidative stress <br>2. Change in urinary hydrogen peroxide excretion<br>3. Change in urinary nitrates excretion<br><br>All measures at baseline, day 1, and 5 post transplantation