ontuberculous mycobacterial cervicofacial lymphadenitis in children; diagnostic performance of the Capilia MAC antibody Elisa test and possible portals of entry
Recruiting
- Conditions
- ontuberculous mycobacterial cervicofacial lymphadenitis
- Registration Number
- NL-OMON24552
- Lead Sponsor
- Board of directors Academic Medical Center, Amsterdam. (This study is an investigator initiated study)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Age between 0-11 years
High clinical suspicion of NTM cervicofacial lymphadenitis with indication for surgical treatment, as defined by the following factors;
Cervicofacial lymphadenopathy for a period longer than 3 weeks
Typical clinical presentation as defined by Penn et al., 2011. (6)
Negative serologic tests for other kinds of (sub) chronical lymphadenopathy:
Epstein-Barr virus, cytomegalovirus, Bartonella species, Adenovirus, and toxoplasmosis Ultrasonographically, hypoechoic lymph nodes, often with central necrosis, nodal matting and adjacent soft tissue oedema
Exclusion Criteria
Known immunodeficiencies
Use of immunosuppressive drugs
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sensitivity and specificity of the Capilia mac antibody Elisa test<br>
- Secondary Outcome Measures
Name Time Method The assessment of microbial composition and identification of NTM in the oral cavity, oropharynx and excised lymph node material.