Clinical Assessment of Patients With High Bone Mass Due to Mutation in Lrp5
- Conditions
- Osteopetrosis
- Registration Number
- NCT01199094
- Lead Sponsor
- Odense University Hospital
- Brief Summary
The aim of the study is to describe patients with a high bone mass phenotype due to a mutation in the low density lipoprotein l receptor 5 gene (LRP5) and compare them with age and sex matched controls. Moreover, bone density and microarchitecture as well as markers of bone metabolism are evaluated
- Detailed Description
Cases and controls are closely matched on age and sex and evaluated cross-sectionally.
Dual x-ray absorptiometry (DXA) and high resolution peripheral quantitative computed tomography (HR-pQCT) are used in order to evaluate bone density as well as microarchitecture. Bone turnover markers and body composition are also measured.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 38
- Lrp5 mutation/ADOI
- Pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bone microarchitecture as assessed by high resolution quantitative computed tomography (HR-pQCT) 12 weeks HR-pQCT is used to evaluate bone microarchitecture, i.e. bone trabeculae, cortical thickness and trabecular number. Aim is to test if the microarchitecture of these patients are different that observed in normal controls
- Secondary Outcome Measures
Name Time Method Changes in bone turnover markers 12 weeks Markers of bone resorption and formation are investigated.
Bone mineral density 12 weeks DXA is used to evaluate bone mineral density at total hip, spine, whole body and forearm.
Trial Locations
- Locations (1)
Odense University Hospital, Osteoporosis Clinic
🇩🇰Odense, Denmark