Sleep Disordered Breathing and Lung Transplantation

• Conditions: Sleep Disordered Breathing; Lung Transplantation

• Registration Number: NCT01179087
• Lead Sponsor: KU Leuven

Brief Summary

The purpose of the study is to investigate the prevalence, clinical predictors and consequences (effect on survival, chronic rejection) of sleep disordered breathing in lung transplant recipients.

Detailed Description

All patients with end-stage respiratory failure who are referred for lung transplantation and are older than 18 years old are enrolled.

We collect:

* Medical history

* Blood pressure

* Anthropometrics

* Pulmonary function

* Arterial blood gas

* Questionnaire (QOL, ESS)

* Sleep diary

* Polysomnography

Study Timeline

• Study Start: 2010-08
• Study First Submitted: 2010-08-09
• Study First Submitted QC: 2010-08-10
• Study First Posted: 2010-08-11
• Status Verified: 2013-08
• Last Update Submitted: 2013-08-05
• Last Update Posted: 2013-08-07
• Primary Completion: 2014-09
• Study Completion: 2014-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients with end-stage respiratory failure who are referred for lung transplantation
• Informed consent from patient

Exclusion Criteria

• Patients who are declined for lung transplantation
• Patients < 18 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of sleep disordered breathing	1 year after lung transplantation	Polysomnographic evaluation

Secondary Outcome Measures

Name	Time	Method
Pulmonary function	1 year after lung transplantation	Effect of SDB on pulmonary function/BOS
Investigate possible relationship between SDB and patient medical history	1 year after lung transplantation

Trial Locations

Locations (1)

Katholieke Universiteit Leuven; 🇧🇪 Leuven, Belgium