A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer
- Conditions
- Non-small Cell Lung CancerNSCLC
- Interventions
- Registration Number
- NCT04746924
- Lead Sponsor
- BeiGene
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of ociperlimab + tislelizumab compared with that of pembrolizumab in adults with PD-L1 high, locally advanced/recurrent or untreated metastatic NSCLC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 662
- Histologically or cytologically documented locally advanced or recurrent non-small cell lung cancer (NSCLC) that is not eligible for curative surgery and/or definitive radiotherapy with or without chemoradiotherapy, or metastatic-nonsquamous or squamous NSCLC.
- No prior systemic treatment for metastatic NSCLC.
- Agreement to provide archival tissue or fresh biopsy (if archival tissue is not available).
- Tumors with PD-L1 expressed in ≥ 50% tumor cells.
- At least 1 measurable lesion as defined per RECIST v1.1.
- ECOG Performance Status ≤ 1.
Key
- Known mutations in the epidermal growth factor receptor (EGFR) gene, anaplastic lymphoma kinase (ALK) fusion oncogene, BRAF V600E, or ROS1.
- Prior therapy with an anti-programmed cell death protein (anti-PD)-1, anti-PD-ligand (L)-1, anti-PD-ligand-2, anti-T-cell immunoglobulin and ITIM (anti-TIGIT) domain, or any other antibody or drug specifically targeting T-cell costimulation or checkpoint pathways.
- Active leptomeningeal disease or uncontrolled, untreated brain metastasis.
- Active autoimmune diseases or history of autoimmune diseases that may relapse.
Note: Other protocol defined Inclusion/Exclusion criteria may apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A: Tislelizumab plus Ociperlimab Tislelizumab Participants will receive tislelizumab 200 milligrams (mg) intravenously followed by ociperlimab 900 mg intravenously once every 3 weeks. Arm B: Pembrolizumab plus Placebo Pembrolizumab Participants will receive pembrolizumab 200 mg intravenously followed by placebo intravenously once every 3 weeks. Arm B: Pembrolizumab plus Placebo Placebo Participants will receive pembrolizumab 200 mg intravenously followed by placebo intravenously once every 3 weeks. Arm C: Tislelizumab plus Placebo Tislelizumab Participants will receive tislelizumab 200 mg intravenously followed by placebo intravenously once every 3 weeks. Arm C: Tislelizumab plus Placebo Placebo Participants will receive tislelizumab 200 mg intravenously followed by placebo intravenously once every 3 weeks. Arm A: Tislelizumab plus Ociperlimab Ociperlimab Participants will receive tislelizumab 200 milligrams (mg) intravenously followed by ociperlimab 900 mg intravenously once every 3 weeks.
- Primary Outcome Measures
Name Time Method Overall Survival (OS) Up to approximately 58 months OS will be defined as the time from the date of randomization to the date of death due to any cause.
- Secondary Outcome Measures
Name Time Method Progression-free Survival (PFS) As Assessed By Investigators Up to approximately 58 months PFS will be defined as the time from the date of randomization to the date of the first objectively documented tumor progression per RECIST v1.1, or death, whichever occurs first.
Overall Response Rate (ORR) As Assessed By Investigators Up to approximately 58 months ORR will be defined as the proportion of participants with a documented, confirmed complete response or partial response per RECIST v1.1.
Duration Of Response (DOR) As Assessed By Investigators Up to approximately 58 months DOR will be defined as the time from the first determination of an objective response per RECIST v1.1 until the first documentation of progression or death, whichever occurs first.
Health-related Quality Of Life (HRQoL): European Organization For Research And Treatment Of Cancer Quality Of Life Questionnaire Core 30 (EORTC QLQ-C30) Within 7 days after permanent treatment discontinuation HRQoL will be assessed via patient-reported outcomes (PRO) using the EORTC QLQ-C30.
The EORTC QLQ-C30 (Version 3) consists of Global health status/QoL (score range from 0=very poor to 7=excellent), 5 functioning scales (physical, role, emotional, cognitive, social), 8 symptom scales (fatigue, nausea/vomiting, pain, dyspnea, insomnia, constipation, diarrhea) and financial difficulties with scores ranging from 1 = "Not at all" to 4 = "Very much". For the global health status/QoL and functioning scales, higher scores indicate better outcomes and for symptom scales, lower scores indicate better outcomes.HRQoL: EORTC Lung Cancer Module Quality of Life Questionnaire Lung Cancer 13 (QLQ-LC13) HRQoL will be assessed via PRO using the EORTC QLQ-LC13. Within 7 days after permanent treatment discontinuation QLQ-LC13 consists of 10 scales, scores ranging from 1 = "not at all" to 4 = "very much", and 2 questions regarding use of pain medication (yes/no) and if yes, did it help (1 = "not at all" to 4 = "very much"). In symptom scales, lower scores indicate better outcomes.
HRQoL: European Quality of Life-5 Level- 5 Dimension (EQ-5D-5L) Questionnaire Within 7 days after permanent treatment discontinuation HRQoL will be assessed via PRO using the EQ-5D-5L. The EQ-5D-5L comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression, and a visual analog scale (VAS). Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems, and extreme problems. The VAS records the respondent's self-rated health on a 0 to 100 scale, with 100 = "the best health you can imagine" and 0 = "'the worst health you can imagine". Lower scores in descriptive dimension indicate better HRQoL and higher VAS scores indicates better health state.
Time To Deterioration (TTD) Within 7 days after permanent treatment discontinuation TTD will be analyzed using PRO scores, and will be defined as worsening scores of ≥10 points from baseline for 2 consecutive assessments or 1 assessment followed by death from any cause.
Number Of Participants Experiencing Adverse Events (AEs) 90 days (±14) after last dose The incidence and severity of AEs will be determined according to National Cancer Institute Common Terminology Criteria for Adverse Events Version 5.0 (NCI CTCAE v5.0).
Trial Locations
- Locations (218)
Centro Medical Austral
🇦🇷Buenos Aires, Argentina
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Northern Cancer Institute
🇦🇺St Leonards, New South Wales, Australia
Calvary Mater Newcastle
🇦🇺Waratah, New South Wales, Australia
The Prince Charles Hospital
🇦🇺Chermside, Queensland, Australia
John Flynn Private Hospital
🇦🇺Tugun, Queensland, Australia
Cancer Institute of Ceara
🇧🇷Fortaleza, Brazil
Cepho Centro de Estudos E Pesquisas de Hematologia E Oncologia
🇧🇷Santo Andre, Brazil
Fujian Cancer Hospital
🇨🇳Fuzhou, Fujian, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
🇨🇳Guangzhou, Guangdong, China
Cancer Hospital of Shantou University Medical College
🇨🇳Shantou, Guangdong, China
Shenzhen Peoples Hospital
🇨🇳Shenzhen, Guangdong, China
The Peoples Hospital of Guangxi Zhuang Autonomous Region
🇨🇳Nanning, Guangxi, China
The Tumor Hospital Affiliated to Guangxi Medical University
🇨🇳Nanning, Guangxi, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, Henan, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, Hubei, China
Hubei Cancer Hospital
🇨🇳Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
Changzhou No Peoples Hospital, the Affiliated Hospital of Nanjing Medical University Branch Cheng
🇨🇳Changzhou, Jiangsu, China
Nanjing First Hospital
🇨🇳Nanjing, Jiangsu, China
Nanjing Chest Hospital
🇨🇳Nanjing, Jiangsu, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Xuzhou Central Hospital
🇨🇳Xuzhou, Jiangsu, China
The First Affiliated Hospital of Soochow University Branch Shizi
🇨🇳Suzhou, Jiangsu, China
Weifang Peoples Hospital
🇨🇳Weifang, Shandong, China
Shanghai Pulmonary Hospital
🇨🇳Shanghai, Shanghai, China
West China Hospital, Sichuan University
🇨🇳Chengdu, Sichuan, China
Hia Begin
🇫🇷saint Mande, France
Israel Georgian Medical Research Clinic Helsicore Ltd
🇬🇪Tbilisi, Georgia
Liaoning Cancer Hospital and Institute
🇨🇳Shenyang, Liaoning, China
The First Affiliated Hospital of Xian Jiaotong University
🇨🇳Xian, Shaanxi, China
The Affiliated Hospital of Qingdao University Branch Laoshan
🇨🇳Qingdao, Shandong, China
Shanghai Chest Hospital
🇨🇳Shanghai, Shanghai, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
Affiliated Cancer Hospital of Xinjiang Medical University
🇨🇳Urumqi, Xinjiang, China
The First Affiliated Hospital of Ningbo University
🇨🇳Ningbo, Zhejiang, China
Centre Hospitalier de La Cote Basque Saint Leon Service de Pneumologie
🇫🇷Bayonne, France
Hopital Louis Pradel
🇫🇷Lyon, France
Yantai Yuhuangding Hospital
🇨🇳Yantai, Shandong, China
Tianjin Medical University Cancer Institute and Hospital
🇨🇳Tianjin, Tianjin, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Icm Val Daurelle Oncologie Medicale
🇫🇷Montpellier, France
Polyclinique de Gentilly
🇫🇷Nancy, France
Hopital Cochin
🇫🇷Paris cedex, France
Chu Hopital Lyon Sud
🇫🇷PierreBenite, France
Affiliated Zhongshan Hospital of Fudan University
🇨🇳Shanghai, Shanghai, China
Shanxi Bethune Hospital
🇨🇳Taiyuan, Shanxi, China
Centre de Lutte Contre Le Cancer Institut Bergonie
🇫🇷Bordeaux, France
Hopital de La Croix Rousse
🇫🇷Lyon, France
Sichuan Cancer Hospital and Institute
🇨🇳Chengdu, Sichuan, China
Affiliated Hospital of North Sichuan Medical College
🇨🇳Nanchong, Sichuan, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang
🇨🇳Taizhou, Zhejiang, China
The Fourth Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Yiwu, Zhejiang, China
Chu de La Reunion
🇫🇷Saint Pierre, France
Chu Nantes Hopital Nord Laennec
🇫🇷SaintHerblain, France
Chu Tours Hopital Bretonneau Service Pneumologie
🇫🇷Tours, France
Jsc Evex Hospitals Tbilisi
🇬🇪Tbilisi, Georgia
Tim Tbilisi Institute of Medicine Ltd
🇬🇪Tbilisi, Georgia
Centre de Lutte Contre Le Cancer Institut de Cancerologie de Louest Rene Gauducheau
🇫🇷SaintHerblain, France
Acad Fridon Todua Medical Center Ltd Research Institute of Clinical Medicine Ltd
🇬🇪Tbilisi, Georgia
Universitaetsklinikum Aachen
🇩🇪Aachen, Germany
High Technology Hospital Medcenter Ltd
🇬🇪Batumi, Georgia
Caucasus Medical Centre Ltd
🇬🇪Tbilisi, Georgia
Multiprofile Clinic Consilium Medulla Ltd
🇬🇪Tbilisi, Georgia
Oncology Research Center Ltd
🇬🇪Tbilisi, Georgia
Jsc German Hospital
🇬🇪Tbilisi, Georgia
Institute of Clinical Oncology Ltd
🇬🇪Tbilisi, Georgia
Universitatsklinikum Bonn
🇩🇪Bonn, Germany
Uniklinikum Giessen Marburg
🇩🇪Giessen, Germany
Lungenclinic Grosshansdorf Gmbh
🇩🇪Grohansdorf, Germany
Ambulantes Krebszentrum Hamburg
🇩🇪Hamburg, Germany
Kliniken Der Stadt Koeln Ggmbh
🇩🇪Koln, Germany
Munchen Klinik Bogenhausen
🇩🇪Munich, Germany
Agaplesion Diakonieklinikum Rotenburg Gemeinnutzige Gmbh
🇩🇪Rotenburg, Germany
Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi
🇮🇹Bologna, Italy
Azienda Ospedaliera Papardo
🇮🇹Messina, Italy
Aou San Luigi Gonzaga
🇮🇹Orbassano, Italy
Nagoya University Hospital
🇯🇵Nagoya, Aichi, Japan
Hirosaki University Hospital
🇯🇵Hirosaki, Aomori, Japan
Nho Shikoku Cancer Center
🇯🇵Matsuyamashi, Ehime, Japan
Kurume University Hospital
🇯🇵Kurume, Fukuoka, Japan
National Hospital Organization Shibukawa Medical Center
🇯🇵Shibukawa, Gunma, Japan
Kobe University Hospital
🇯🇵Kobe, Hyogo, Japan
Kobe City Medical Center General Hospital
🇯🇵Kobe, Hyogo, Japan
Hyogo Medical University Hospital
🇯🇵Nishinomiyashi, Hyogo, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Ishikawa, Japan
Kanagawa Cancer Center
🇯🇵Yokohamashi, Kanagawa, Japan
Miyagi Cancer Center
🇯🇵Natorishi, Miyagi, Japan
Okayama University Hospital
🇯🇵Okayamashi, Okayama, Japan
Kansai Medical University Hospital
🇯🇵Hirakata, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama, Osaka, Japan
National Hospital Organization Kinki Chuo Chest Medical Center
🇯🇵Sakai, Osaka, Japan
Osaka Toneyama Medical Center
🇯🇵Toyonaka, Osaka, Japan
Jichi Medical University Hospital
🇯🇵Shimonotsuke, Tochigi, Japan
Dokkyo Medical University Hospital
🇯🇵Shimotsugagun, Tochigi, Japan
Tochigi Cancer Center
🇯🇵Utsunomiya, Tochigi, Japan
Nippon Medical School Hospital
🇯🇵Bunkyoku, Tokyo, Japan
Cancer Institute Hospital of Jfcr
🇯🇵Kotoku, Tokyo, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata, Japan
Chungbuk National University Hospital
🇰🇷Cheongjusi, Chungcheongbukdo, Korea, Republic of
Keimyung University Dongsan Hospital
🇰🇷Dalseogu, Daegu Gwang'yeogsi, Korea, Republic of
The Catholic University of Korea Bucheon St Marys Hospital
🇰🇷BucheonSi, Gyeonggi-do, Korea, Republic of
Cha Bundang Medical Center, Cha University
🇰🇷Gyeonggido, Gyeonggi-do, Korea, Republic of
The Catholic University of Korea, St Vincents Hospital
🇰🇷Suwonsi, Gyeonggi-do, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Gyeongsangbukdo, Korea, Republic of
The Catholic University of Korea, Eunpyeong St Marys Hospital
🇰🇷Eunpyeonggu, Seoul Teugbyeolsi, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Meander Medisch Centrum
🇳🇱Amersfoort, Netherlands
Rijnstate
🇳🇱Arnhem, Netherlands
Ziekenhuis St Jansdal
🇳🇱Harderwijk, Netherlands
Stichting Zuyderland Medisch Centrum
🇳🇱Heerlen, Netherlands
Isala Klinieken Zwolle
🇳🇱Zwolle, Netherlands
Uniwersytecki Szpital Kliniczny W Bialymstoku
🇵🇱Bialystok, Poland
Centrum Terapii Wspoczesnej
🇵🇱Lodz, Poland
Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi
🇵🇱Lodz, Poland
Wielkopolskie Centrum Pulmonologii I Torakochirurgii
🇵🇱Poznan, Poland
Przychodnia Med Polonia Sp Z Oo
🇵🇱Poznan, Poland
Etg Zamosc
🇵🇱Zamosc, Poland
Arkhangelsk Regional Clinical Oncological Dispensary
🇷🇺Arkhangelsk, Arkhangel'skaya Oblast', Russian Federation
State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the Republic
🇷🇺Ufa, Bashkortostan, Respublika, Russian Federation
State Budgetary Healthcare Institution Regional Oncology Dispensary Number
🇷🇺Magnitogorsk, Chelyabinskaya Oblast', Russian Federation
Vitamed Llc
🇷🇺Moscow, Moskva, Russian Federation
State Budgetary Healthcare Institution Nizhny Novgorod Regional Clinical Oncology Dispensary
🇷🇺Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation
Bih of Omsk Region Clinical Oncology Dispensary
🇷🇺Omsk, Omskaya Oblast', Russian Federation
State Budgetary Healthcare Institution Samara Regional Clinical Oncology Dispensary
🇷🇺Samara, Samaraskaya Oblast', Russian Federation
Llc Av Medical Group
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Hospital Universitario Fundacion Alcorcon
🇪🇸Alcorcon, Spain
Hospital Del Mar
🇪🇸Barcelona, Spain
Hospital de La Santa Creu I Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitario Vall Dhebron
🇪🇸Barcelona, Spain
Hospital Universitari Quiron Dexeus
🇪🇸Barcelona, Spain
Hospital General Universitario de Elche
🇪🇸Elche, Spain
Ico Girona
🇪🇸Girona, Spain
Hospital Universitario de Jaen
🇪🇸Jaen, Spain
Complejo Hospitalario Universitario Insular Gran Canaria
🇪🇸Las Palmas, Spain
Hospital Universitario Lucus Augusti
🇪🇸Lugo, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Start Madrid Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Universitario Doce de Octubre
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
Hospital Regional Universitario de Malaga
🇪🇸Malaga, Spain
Hospital Universitario Virgen de La Victoria
🇪🇸Malaga, Spain
Hospital General Universitario Morales Meseguer
🇪🇸Murcia, Spain
Complexo Hospitalario Universitario de Ourense
🇪🇸Orense, Spain
Hospital Universitari Son Espases
🇪🇸Palma de Mallorca, Spain
Hospital Universitario Virgen Del Rocio
🇪🇸Sevilla, Spain
Hospital Universitario Nuestra Senora de Valme
🇪🇸Sevilla, Spain
Hospital Arnau de Vilanova
🇪🇸Valencia, Spain
Hospital Universitari I Politecnic La Fe
🇪🇸Valencia, Spain
Changhua Christian Hospital
🇨🇳Changhua, Taiwan
Kaohsiung Chang Gung Memorial Hospital
🇨🇳Kaohsiung, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Taipei Tzu Chi Hospital
🇨🇳Taipei, Taiwan
Linkou Chang Gung Memorial Hospital
🇨🇳Taoyuan, Taiwan
National Taiwan University Hospital Yunlin Branch
🇨🇳Yunlin, Taiwan
Siriraj Hospital
🇹🇭Bangkok, Thailand
Songklanagarind Hospital (Prince of Songkhla University)
🇹🇭Hat Yai, Thailand
Chulabhorn Research Institute
🇹🇭Lak Si, Thailand
Srinagarind Hospital (Khon Kaen University)
🇹🇭Muang, Thailand
Maharaj Nakorn Chiang Mai Hospital (Chiang Mai University)
🇹🇭Muang, Thailand
Phramongkutklao Hospital
🇹🇭Ratchathewi, Thailand
Rajavithi Hospital
🇹🇭Ratchathewi, Thailand
Acibadem Adana Hospital
🇹🇷Adana, Turkey
Baskent University Practice and Research Hospital Adana Medical Oncology Department
🇹🇷Adana, Turkey
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
🇹🇷Ankara, Turkey
Memorial Ankara Hospital
🇹🇷Ankara, Turkey
Inonu Universitesi Tip Fakultesi
🇹🇷Battalgazi, Turkey
Tr Trakya University Health Research and Application Center (Hospital)
🇹🇷Edirne, Turkey
Iu C, Clinical Research Excellence Application and Research Center
🇹🇷Istanbul, Turkey
Tr Ministry of Health Goztepe Prof Dr Suleyman Yalcin City Hospital
🇹🇷Istanbul, Turkey
Ege University Medical Faculty
🇹🇷Izmir, Turkey
Kocaeli Universitesi Tip Fakultesi
🇹🇷Kocaeli, Turkey
Necmettin Erbakan University Selcuklu Faculty of Medicine
🇹🇷Meram, Turkey
Mersin City Hospital
🇹🇷Mersin City Hospital, Turkey
Medical Center of Limited Liability Company Mriya Med Service
🇺🇦Kryvyi Rih, Ukraine
Zakarpatska Regional Clinical Oncological Center
🇺🇦Uzhgorod, Ukraine
Communal Non Profit Enterprisecentral Municipal Clinical Hospital of Uzhhorod City Council
🇺🇦Uzhhorod, Ukraine
Providence Medical Foundation St Jude Heritage Healthcare
🇺🇸Fullerton, California, United States
Valkyrie Clinical Trials
🇺🇸Los Angeles, California, United States
Ocala Oncology Center Pl Dba Florida Cancer Affiliates Ocala
🇺🇸Ocala, Florida, United States
Advent Health Cancer Institute
🇺🇸Orlando, Florida, United States
Goshen Center For Cancer Care
🇺🇸Goshen, Indiana, United States
Baptist Health Lexington
🇺🇸Lexington, Kentucky, United States
University Medical Center New Orleans West Jefferson Medical Center
🇺🇸New Orleans, Louisiana, United States
Metro Minnesota Community Oncology Research Consortium (Mmcorc)
🇺🇸Saint Paul, Minnesota, United States
West Penn Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Centro Para La Atencion Del Paciente Oncologico (Caipo)
🇦🇷Tucuman, Argentina
Pindara Private Hospital
🇦🇺Benowa, Queensland, Australia
Mater Cancer Care Centre
🇦🇺South Brisbane, Queensland, Australia
Lyell McEwin Hospital
🇦🇺Elizabeth Vale, South Australia, Australia
Ballarat Health Services
🇦🇺Ballarat, Victoria, Australia
Monash Health
🇦🇺Clayton, Victoria, Australia
Western Health Sunshine Hospital
🇦🇺St Albans, Victoria, Australia
St John of God, Murdoch
🇦🇺Murdoch, Western Australia, Australia
Instituto Dor de Pesquisa E Ensino Distrito Federal
🇧🇷Brasilia, Brazil
Hospital Evangelico de Cachoeiro de Itapemirim
🇧🇷Cachoeiro de Itapemirim, Brazil
Centro de Pesquisas Oncologicas Cepon
🇧🇷Florianopolis, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
🇧🇷Sao Jose do Rio Preto, Brazil
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
The Second Hospital of Anhui Medical University
🇨🇳Hefei, Anhui, China
Beijing Chao Yang Hospital
🇨🇳Beijing, Beijing, China
Beijing Cancer Hospital
🇨🇳Beijing, Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, Beijing, China
Beijing Chest Hospital, Capital Medical University
🇨🇳Beijing, Beijing, China
Chongqing Cancer Hospital
🇨🇳Chongqing, Chongqing, China
The First Affiliated Hospital of Army Military Medical University
🇨🇳Chongqing, Chongqing, China
Daping Hospital, Third Military Medical University
🇨🇳Chongqing, Chongqing, China
Chongqing University Three Gorges Central Hospital
🇨🇳Chongqing, Chongqing, China
Fujian Medical University Union Hospital
🇨🇳Fuzhou, Fujian, China