The effect of Lactobacillus acidophilus eBifidobacterium lactis on hepatic steatosis and difficulty in insulin action in obese adolescents: A randomized clinical trial

Not Applicable

• Conditions: Pediatric Obesity; Obesity due to excess calories; Fatty (change of) liver, not elsewhere classified; Fatty Liver; Insulin Resistance; Other specified endocrine disorders; C18.654.726.500.720; E66.0; C06.552.241; K76.0

• Registration Number: RBR-9n7kfw
• Lead Sponsor: Escola Bahiana de Medicina e Saúde Pública

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-09-30
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Adolescents between 10 to 19 years old; Diagnosis of obesity, based on the BMI/age indicator above +2 z scores of the WHO reference curve; Previous ultrasound diagnosis of Non-Alcoholic Fatty Liver Disease; Signature of the Review Board Authorization Form; Previous history of attendance to the service (absence of absences in the previous year); Absence of diabetes mellitus (fasting blood glucose below 100 mg/dl); Living in Salvador or metropolitan urban area;

Exclusion Criteria

Presence of endogenous obesity; Presence of psychiatric comorbidity or disease that interferes with weight evolution; Use of medications such as metformin, statins, laxatives, antibiotics, antidepressants, corticosteroids, anxiolytics and / or any other medication that may interfere with the gut microbiota; Be classified as SGA (Small for Gestational Age) at birth;

Study & Design

• Study Type: Intervention
• Study Design: Not specified