Heading in football: impact on neural blood biomarkers

Recruiting

• Conditions: brain damage; Neurodegeneration; 10014623

• Registration Number: NL-OMON53582
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 280

Inclusion Criteria

- Member of the KNVB
- 18 years or older
- Male
- Self-reported fitness to play 70-90 minutes

Exclusion Criteria

- Sustained a head injury in the last year
- History or current neurological condition
- Regular participation in other contact sports (e.g. rugby, American football,
ice hockey, fighting sports)
- (Former) military personnel with a history of fighting/blast exposure

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the change in concentration of neurofilament light<br /><br>after playing a football match with naturalistic heading exposure. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are the change in concentration of GFAP, p-Tau,<br /><br>S100B, NSE and beta-synuclein in blood after playing a football match with<br /><br>naturalistic heading exposure. Other study parameters are demographic<br /><br>variables, medical history, heading characteristics, exercise intensity, and<br /><br>genetic risk factors for neurodegenerative disease.</p><br>