GABA From Medical Nutrition to Pancreatic Beta-cell Regeneration
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- gaba decrease anti gad antibodies
Study Overview
Brief Summary
GABA(gamma-Aminobutyric acid) may be used for decreasing anti-gad antibodies and leads beta-cell regeneration.
Detailed Description
100 patients with type I diabetes were in 2 groups, had been monitored in a private clinic, number 50 each group, with 30 females and 20 males after the written consent of all patients.
All the patients Lied between 18-25 years old with 5-10 years of diabetes onset.
The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.
The second group was only on insulin injection in the form of toujeo once daily and Novorapid 3 times daily.
In the first group;the investigator measured fasting c peptide levels before and after 6 months of GABA 750mg daily.Also,the investigator measured anti gad antibodies before and after 6 months of treatment.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 25 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •type 1 diabetes patients age from 18 to 25 years on basal bolus insulin
Exclusion Criteria
- •thyroid problems liver disease kidney disease
Arms & Interventions
group1 on GABA
The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.
Intervention: GABA (Drug)
Outcomes
Primary Outcomes
gaba decrease anti gad antibodies
Time Frame: 6 months
gaba 750 mg daily for type 1 diabetes patients
gaba improve c peptide levels
Time Frame: 6 months
gaba 750 mg pe day for type 1 diabetes patients
Secondary Outcomes
No secondary outcomes reported
Investigators
mahmoud younis
consultant
Ministry of Health and Population, Egypt