GABA From Medical Nutrition to Pancreatic Beta-cell Regeneration
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- gaba decrease anti gad antibodies
研究概览
简要总结
GABA(gamma-Aminobutyric acid) may be used for decreasing anti-gad antibodies and leads beta-cell regeneration.
详细描述
100 patients with type I diabetes were in 2 groups, had been monitored in a private clinic, number 50 each group, with 30 females and 20 males after the written consent of all patients.
All the patients Lied between 18-25 years old with 5-10 years of diabetes onset.
The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.
The second group was only on insulin injection in the form of toujeo once daily and Novorapid 3 times daily.
In the first group;the investigator measured fasting c peptide levels before and after 6 months of GABA 750mg daily.Also,the investigator measured anti gad antibodies before and after 6 months of treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •type 1 diabetes patients age from 18 to 25 years on basal bolus insulin
排除标准
- •thyroid problems liver disease kidney disease
研究组 & 干预措施
group1 on GABA
The first group was on insulin therapy in the form of toujeo once daily and Novorapid 3 times daily and they received GABA nutritional supplement 750mg per day.
干预措施: GABA (Drug)
结局指标
主要结局
gaba decrease anti gad antibodies
时间窗: 6 months
gaba 750 mg daily for type 1 diabetes patients
gaba improve c peptide levels
时间窗: 6 months
gaba 750 mg pe day for type 1 diabetes patients
次要结局
未报告次要终点
研究者
mahmoud younis
consultant
Ministry of Health and Population, Egypt