Perioperative changes in the microvascular perfused boundry region in patients undergoing coronary artery bypass grafting
- Conditions
- Microcirculation, Glycocalyx, Cardiac surgery, Heparin, Cardiovascular disease
- Registration Number
- NL-OMON21929
- Lead Sponsor
- VU University Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 44
Inclusion Criteria
adult patients (age 18-85 years) undergoing CABG surgery, informed consent
Exclusion Criteria
Re-operation, emergency operation, patients with diabetes mellitus type 1, patients with a history of hematologic or hepatic diseases or renal replacement therapy, patients with a Body Mass Index (BMI) over 35 kg/m2
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Perioperative changes in the perfused boundry region (PBR) of the sublingual microvasculature
- Secondary Outcome Measures
Name Time Method Perioperative changes in plasma markers for shedding of the glycocalyx such as heparan sulfate, hyaluronic acid and syndecan-1