Evaluation of the Effects of Injectable Platelet-Rich Fibrin (PRF) and Its Combination with Low-Intensity Laser Therapy on the Speed of Canine Tooth Movement During Braces Treatment: A Randomized Controlled Trial.

Phase 3

Not yet recruiting

• Conditions: Disorder of teeth and supporting structures, unspecified, (2) ICD-10 Condition: K089||Disorder of teeth and supporting structures, unspecified,

• Registration Number: CTRI/2025/06/088422
• Lead Sponsor: Pratiksha Gajanan Wadekar

Brief Summary

Orthodontic treatment is a long process and it is one of the major concerns. To counteract this problem, there is a need to increase the rate of tooth movement. Various methods that can increase the rate of orthodontic tooth movement and reduce the treatment time, includes non-surgical methods like low intensity laser therapy, local injections of prostaglandins, 1, 25(OH)2D3 (the active form of vitamin D3), osteocalcin and Relaxin around the alveolar socket. Among this I-PRF & LILT are noninvasive options for accelerating the orthodontic tooth movement (OTM). Therefore, the aim of this study is to  evaluate effects of I-PRF and combination of I-PRF & LILT on the rate of canine retraction.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-04-06
• Study Start: 2025-06-16

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Patients of either sex with age group of 15-25 years.
• Angles class I or class II Division 1 malocclusion with Bimaxillary protrusion.

Exclusion Criteria

• Patients with previous history of orthodontic treatment Patient with canine having dilacerated roots.
• Patients with impacted canine.
• Patients with sign of gingival or periodontal disease.
• Patients with metabolic disorders that leads to bone pathologies.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fibrin and combination of Injectable Platelet	•T0: at the start of canine retraction. | •T1: at 1 st month after the start of canine retraction. | •T2: at 2 nd month after the start of canine retraction. | •T3: at 3 rd month after the start of canine retraction. | •T4: at the end of canine retraction.
To evaluate effects of Injectable Platelet Rich	•T0: at the start of canine retraction. | •T1: at 1 st month after the start of canine retraction. | •T2: at 2 nd month after the start of canine retraction. | •T3: at 3 rd month after the start of canine retraction. | •T4: at the end of canine retraction.
Rich Fibrin and Low Intensity Laser Therapy on	•T0: at the start of canine retraction. | •T1: at 1 st month after the start of canine retraction. | •T2: at 2 nd month after the start of canine retraction. | •T3: at 3 rd month after the start of canine retraction. | •T4: at the end of canine retraction.
the rate of canine retraction	•T0: at the start of canine retraction. | •T1: at 1 st month after the start of canine retraction. | •T2: at 2 nd month after the start of canine retraction. | •T3: at 3 rd month after the start of canine retraction. | •T4: at the end of canine retraction.

Secondary Outcome Measures

Name	Time	Method
To compare effects of Injectable Platelet Rich	Fibrin & combination of Injectable Platelet Rich

Trial Locations

Locations (1)

Government Dental College and Hospital, nagpur; 🇮🇳 Nagpur, MAHARASHTRA, India

Government Dental College and Hospital, nagpur

🇮🇳Nagpur, MAHARASHTRA, India

Dr Pratiksha Wadekar

Principal investigator

9579335843

pratikshaw249@gmail.com