Effect of platelet rich fibrin matrix (PRFM) and demineralized freeze-dried bone allograft (DFDBA) in immediate implant.

Not yet recruiting

Conditions: Teeth indicated for extraction
Retained dental root,

Registration Number: CTRI/2020/11/028974

Lead Sponsor: The Indian Council of Medical Research

Brief Summary: BACKGROUND: Implantdentistry has evolved over time with various novel protocols. These protocolshave guided in making the implant placement easier to a point that now theoutcomes can be predicted to a greater extent. Research using biomaterials suchas blood derived membranes and bone grafts have assisted in constant success ofthis therapy. Several strategies includingplacement of immediate implants have been proposed to preserve post extractionalveolar ridge from resorption during healing. The immediate implant treatmentprotocol serves many advantages including minimal surgical interventions, thusreducing total treatment time, preservation of adequate bone height and aestheticoutcomes especially in anterior region.

AIM: This study will be undertaken to evaluate effectiveness of implantplacement immediately followed by tooth removal with simultaneous PRFM andDFDBA grafting using a two-stage protocol.

MATERIAL AND METHODS: Thisstudy will be performed over one year period. Twelve patients, each having onetooth indicated for extraction in the maxilla and/or mandible will be selected.Implants will be placed into fresh extraction socket after augmentation withautologous platelet concentrate and bone graft, using two stage protocol.Second stage study will be performed 5-6 months following implant placement.Abutments will be connected within 3-6 weeks and definitive metal ceramicrestoration will be placed.

EXPECTED RESULTS:The success of the implant will be determined by the crestal bone changes andstability after 6 months following the use of PRFM and Bone graft (DFDBA).

CONCLUSION: Theaugmentation procedures have proved to be effective to achieve bone fill aswell as resolution of bone defects in surrounding implants. Bone augmentationalong with simultaneous implant placement may result in reduction of horizontalbone resorption.

KEYWORDS:Immediate implant, PRFM, DFDBA, Extraction socket, Atraumatic extraction.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 12

Inclusion Criteria

1.Tooth which needs extraction due to root fractures, endodontic failures, internal and external resorption, over-retained deciduous teeth, non-restorable carious lesions, residual roots.
2.Good oral hygiene described as full mouth plaque score of â‰¤ 25%.
3.Presence of opposing natural tooth.
4.Presence of adjacent teeth.
5.Thick gingival biotype.
6.Radiographic and clinical appearance of intact alveolar bony walls.
7.Presence of â‰¥4 mm of bone beyond root apex.
8.D-1, D-2 or D-3 bone quality.

Exclusion Criteria

Systemic diseases that compromise bone healing process e.g. (diabetes, bleeding disorders, osteoporosis and allergies to titanium).
2.Severe maxilla-mandibular space discrepancies.
3.Para functional habits like bruxism and/or clenching.
4.Teeth with interdental spacing/ Proclinated teeth/Rotated or mal-aligned anterior teeth.
5.History of alcoholism, excessive smoking or drug abuse.
6.D-4 bone quality.
7.Width of keratinized gingiva less than 2mm at implant site.
9.Untreated dental diseases.
10.Pregnant and lactating mothers.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
vertical and horizontal crestal bone changes around immediately placed implants.	6 months

Secondary Outcome Measures

Name	Time	Method
implant mobiliy.	baseline, 3 months and 6 months

Trial Locations

Locations (1): Sharad Pawar Dental College
🇮🇳
Wardha, MAHARASHTRA, India
Sharad Pawar Dental College
🇮🇳Wardha, MAHARASHTRA, India
Dr Komal Bhombe
Principal investigator
8805259554
kbhombe@gmail.com