Early initiation of extracorporeal life support in refractory out-of-hospital cardiac arrest

Completed

• Conditions: Cardiac arrest; ventricular fibrilation; 10019280

• Registration Number: NL-OMON55387
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 134

Inclusion Criteria

- ventricular fibrilation
- <=70 years
- >=18 years
- > 15 minutes no circulation
- whitnessed out-of-hospital cardiac arrest
- Bystander BLS

Exclusion Criteria

- ROSC within 15 minutes of conventional CPR with sustained hemodynamic recovery
- Terminal heart failure (NYHA III or IV)
- Severe pulmonary disease (COPD GIII of GIV)
- Disseminated oncological disease
- Obvious or suspected pregnancy
- Bilateral femoral bypass surgery
- Known contraindications for ECPR
- Known pre-arrest Cerebral Performance Category 3 or 4
- Known limitations in therapy or a Do Not Resuscitate-order
- Multi-trauma (Injury Severity Score >15)
- > 60 minutes before start cannulation procedure

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>30-days survival rate with favourable neurological status (Cerebral Performance<br /><br>Category (CPC) score of 1 or 2)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>neurological outcome at 3 months, 6 months and 12 months, survival benefit<br /><br>(Quality Adjusted Life Years, QALY), costs per QALY</p><br>