Viral Triggers in Pediatric Lung Transplantation

Completed

• Conditions: Lung Transplant; Obliterative Bronchiolitis; Bronchiolitis Obliterans

• Registration Number: NCT00891865
• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Brief Summary

The purpose of this study is to determine whether respiratory viral infections increase the risk of bronchiolitis obliterans syndrome (BOS), obliterative bronchiolitis (OB), death, or retransplantation in children who have received lung transplants.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-04-29
• Study First Submitted QC: 2009-04-29
• Study First Posted: 2009-05-01
• Study Start: 2009-06
• Primary Completion: 2015-04
• Study Completion: 2015-04
• Status Verified: 2020-06
• Last Update Submitted: 2020-06-30
• Last Update Posted: 2020-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

• Parent or legal guardian willing and able to provide informed consent
• Participant of first single or bilateral heart-lung transplant

Exclusion Criteria

• Recipient of multi-organ transplant (aside from heart-lung)
• Condition or characteristic which in the opinion of the investigator makes the participant unlikely to complete the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The earliest time to BOS or OB, retransplantation or death	Within 24 months of transplant

Secondary Outcome Measures

Name	Time	Method
Time to each of the following events: BOS or OB, retransplantation or death	Within 24 months of transplant

Trial Locations

Locations (6)

Stanford University; 🇺🇸 Palo Alto, California, United States

Nationwide Children's Hospital; 🇺🇸 Columbus, Ohio, United States

Texas Children's Hospital; 🇺🇸 Houston, Texas, United States

Children's Hospital Boston; 🇺🇸 Boston, Massachusetts, United States

Washington University; 🇺🇸 Saint Louis, Missouri, United States

Children's Hospital of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States