Specific Respiratory Infections as Triggers of Acute Medical Events
- Conditions
- Respiratory Syncytial Virus InfectionsRhinovirusParainfluenzaHuman Metapneumovirus PneumoniaAdenovirusInfluenza, HumanCardiovascular Diseases
- Registration Number
- NCT02984280
- Lead Sponsor
- University College, London
- Brief Summary
This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and Hospital Episode Statistics.
- Detailed Description
We will conduct a time series study correlating anonymised population level data on all samples from NHS laboratories testing positive for six common respiratory viruses with admissions to NHS hospitals in England for a range of cardiac and vascular outcomes over the time period 01/01/2004 to 31/12/2014. This will involve generating Poisson regression models controlling for factors such as seasonal and long-term trends, environmental temperature and humidity.
This study is funded by an Academy of Medical Sciences Starter Grant for Clinical Lecturers.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 787000
- Any individual with a record of an eligible outcome (ICD-10 coded hospitalisation for myocardial infarction or stroke) within the study period aged 45+ years
- Any individual with a record of an eligible exposure (laboratory-confirmed respiratory virus) within the study period at any age
- Outcome events occurring in people aged <45 years
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute myocardial infarction 01/01/2004 to 31/12/2014 ICD-10 coded
Stroke 01/01/2004 to 31/12/2014 ICD-10 coded
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University College London (UCL)
🇬🇧London, United Kingdom